(Q40762488)

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Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

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scholarly article

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Europe PubMed Central

PMC publication ID

23 September 2017

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains (English)

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Plasmodium falciparum

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6

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

object named as

Stanley C Xie

2

0 references

object named as

James McCaw

5

0 references

Susan A. Charman

object named as

Susan A Charman

7

0 references

3

object named as

Pengxing Cao

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

author name string

Tuo Yang

1

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Carlo Giannangelo

4

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Nectarios Klonis

8

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Leann Tilley

9

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Europe PubMed Central

PMC publication ID

23 September 2017

language of work or name

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publication date

9 May 2016

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

PMC publication ID

23 September 2017

60

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Europe PubMed Central

PMC publication ID

23 September 2017

8

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

4501-4510

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

1 reference

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24 September 2017

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

1 reference

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24 September 2017

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Use of Model-Based Nutrient Feeding for Improved Production of Artemisinin by Hairy Roots of Artemisia Annua in a Modified Stirred Tank Bioreactor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Malaria medicines: a glass half full?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Artemisinin resistance--modelling the potential human and economic costs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Optimal assay design for determining the in vitro sensitivity of ring stage Plasmodium falciparum to artemisinins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Arterolane maleate plus piperaquine phosphate for treatment of uncomplicated Plasmodium falciparum malaria: a comparative, multicenter, randomized clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Arterolane, a new synthetic trioxolane for treatment of uncomplicated Plasmodium falciparum malaria: a phase II, multicenter, randomized, dose-finding clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

The molecular mechanism of action of artemisinin--the debate continues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Artemisinin Resistance in Plasmodium falciparum Malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Identification of an antimalarial synthetic trioxolane drug development candidate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Synthetic peroxides as antimalarials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

24 September 2017

New synchronization method for Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

17 June 2018

Dual labeling with a far red probe permits analysis of growth and oxidative stress in P. falciparum-infected erythrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

17 June 2018

Artemisinin and heme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

17 June 2018

Photoaffinity labeling of chloroquine-binding proteins in Plasmodium falciparum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

17 June 2018

Safety, tolerability and pharmacokinetic profile of single and multiple oral doses of arterolane (RBx11160) maleate in healthy subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

19 August 2018

Pharmacokinetics and pharmacodynamics of arterolane maleate following multiple oral doses in adult patients with P. falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

19 August 2018

The production of artemisinin precursors in tobacco

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

19 August 2018

Malaria's drug miracle in danger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

19 August 2018

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4958167

19 August 2018

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/27161632

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides

1 reference

https://pubmed.ncbi.nlm.nih.gov/27161632

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00574-16

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

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