(Q40860042)

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The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-alpha receptors.

scientific article published on July 2000

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scholarly article

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9 November 2019

The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-alpha receptors (English)

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9 November 2019

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9 November 2019

Mariano Esteban

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Esteban M

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1 July 2000

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9 November 2019

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9 November 2019

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9 November 2019

3665-3674

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9 November 2019

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9 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1203710

0 references

Death receptors: signaling and modulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203710

21 January 2018

Apoptosis control by death and decoy receptors

1 reference

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21 January 2018

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

1 reference

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21 January 2018

Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.

1 reference

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21 January 2018

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1 reference

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21 January 2018

African swine fever virus gene A179L, a viral homologue of bcl-2, protects cells from programmed cell death

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21 January 2018

A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system

1 reference

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21 January 2018

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

1 reference

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21 January 2018

Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway

1 reference

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21 January 2018

The double-stranded RNA-dependent protein kinase PKR: structure and function

1 reference

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21 January 2018

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

1 reference

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21 January 2018

The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

1 reference

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21 January 2018

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1 reference

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21 January 2018

Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays

1 reference

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21 January 2018

Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells.

1 reference

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21 January 2018

Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase PKR induces apoptosis and fas receptor expression

1 reference

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21 January 2018

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1 reference

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21 January 2018

Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.

1 reference

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21 January 2018

Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.

1 reference

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21 January 2018

Differential requirement for caspase 9 in apoptotic pathways in vivo.

1 reference

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21 January 2018

Translational control in mammalian cells

1 reference

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21 January 2018

Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis

1 reference

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21 January 2018

Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

1 reference

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21 January 2018

Inhibition of death receptor signals by cellular FLIP

1 reference

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21 January 2018

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1 reference

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21 January 2018

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

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21 January 2018

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

1 reference

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21 January 2018

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

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21 January 2018

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

1 reference

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21 January 2018

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1 reference

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21 January 2018

Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs.

1 reference

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21 January 2018

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

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21 January 2018

Caspases: killer proteases

1 reference

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21 January 2018

Detection and typing of molluscum contagiosum virus in skin lesions by using a simple lysis method and polymerase chain reaction

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21 January 2018

E1B 19K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE.

1 reference

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21 January 2018

Double identity for proteins of the Bcl-2 family

1 reference

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21 January 2018

Two CD95 (APO-1/Fas) signaling pathways

1 reference

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21 January 2018

Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes

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21 January 2018

Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis

1 reference

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21 January 2018

Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase

1 reference

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21 January 2018

How cells respond to interferons

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21 January 2018

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

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21 January 2018

Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism

1 reference

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21 January 2018

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1 reference

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21 January 2018

Caspases: enemies within

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21 January 2018

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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21 January 2018

The fight of viruses against apoptosis

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21 January 2018

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

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21 January 2018

Transcription stimulation of the Fas-encoding gene by nuclear factor for interleukin-6 expression upon influenza virus infection

1 reference

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21 January 2018

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

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21 January 2018

PKR; a sentinel kinase for cellular stress

1 reference

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Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1 reference

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FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

1 reference

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Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cells

1 reference

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21 January 2018

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

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21 January 2018

Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95

1 reference

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21 January 2018

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1 reference

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21 January 2018

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

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21 January 2018

The Interferon-Induced Double-Stranded RNA-Activated Human p68 Protein Kinase Potently Inhibits Protein Synthesis in Cultured Cells

1 reference

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A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Regulated expression of the interferon-induced protein kinase p68 (PKR) by vaccinia virus recombinants inhibits the replication of vesicular stomatitis virus but not that of poliovirus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203710

7 January 2021

based on heuristic

inferred from DOI database lookup

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203710

7 January 2021

based on heuristic

inferred from DOI database lookup

The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203710

7 January 2021

based on heuristic

inferred from DOI database lookup

General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203710

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of fas death signals by FLIPs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203710

7 January 2021

based on heuristic

inferred from DOI database lookup

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203710

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1203710

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10951573%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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1 reference

Europe PubMed Central

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9 November 2019

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