(Q40928348)

English

Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.

scientific article published on September 1999

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scholarly article

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31 October 2019

Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490827%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Dolores Pérez-Sala

2

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31 October 2019

author name string

Rebollo A

1

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31 October 2019

Martínez-A C

3

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31 October 2019

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publication date

1 September 1999

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31 October 2019

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31 October 2019

18

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31 October 2019

4930-4939

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31 October 2019

35

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31 October 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1202875

0 references

Protein lipidation in cell signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Phosphorylation of Bcl-2 protein and association with p21Ras in Ras-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Ras signalling and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Bcl-2 associates with the ras-related protein R-ras p23

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Association of phosphatidylinositol 3 kinase to protein kinase C zeta during interleukin-2 stimulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Ras activation leads to cell proliferation or apoptotic cell death upon interleukin-2 stimulation or lymphokine deprivation, respectively

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Rho GTPases and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's

1 reference

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21 January 2018

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

The regulation and function of p21ras during T-cell activation and growth.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

High-affinity and intermediate-affinity forms of the human interleukin 2 receptor, expressed in an interleukin 9-dependent murine T cell line, deliver proliferative signals via differences in their transduction pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Rho-related proteins: actin cytoskeleton and cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Evidence for a high affinity, saturable, prenylation-dependent p21Ha-ras binding site in plasma membranes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Cloning of the gamma chain of the human IL-2 receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Bcl-2 targets the protein kinase Raf-1 to mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

The genetic regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

21 January 2018

K-ras modulates the cell cycle via both positive and negative regulatory pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202875

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1202875

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490827%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

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1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490827%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

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