(Q40980675)

English

Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy μ opioid receptor/δ opioid receptor ligands

scientific article published on 4 May 2015

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scholarly article

1 reference

Europe PubMed Central

25 September 2017

Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy μ opioid receptor/δ opioid receptor ligands (English)

1 reference

Europe PubMed Central

25 September 2017

0 references

author name string

Aaron M Bender

1

1 reference

Europe PubMed Central

25 September 2017

Nicholas W Griggs

2

1 reference

Europe PubMed Central

25 September 2017

Jessica P Anand

3

1 reference

Europe PubMed Central

25 September 2017

John R Traynor

4

1 reference

Europe PubMed Central

25 September 2017

Emily M Jutkiewicz

5

1 reference

Europe PubMed Central

25 September 2017

Henry I Mosberg

6

1 reference

Europe PubMed Central

25 September 2017

publication date

4 May 2015

1 reference

Europe PubMed Central

25 September 2017

ACS Chemical Neuroscience

1 reference

Europe PubMed Central

25 September 2017

6

1 reference

Europe PubMed Central

25 September 2017

8

1 reference

Europe PubMed Central

25 September 2017

1428-1435

1 reference

Europe PubMed Central

25 September 2017

CNS drug design: balancing physicochemical properties for optimal brain exposure

1 reference

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Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance

1 reference

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[Dmt(1)]DALDA analogues with enhanced μ opioid agonist potency and with a mixed μ/κ opioid activity profile

1 reference

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Mixed κ/μ partial opioid agonists as potential treatments for cocaine dependence

1 reference

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Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity

1 reference

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25 September 2017

Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676711

25 September 2017

Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands

1 reference

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25 September 2017

14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects

1 reference

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25 September 2017

Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models

1 reference

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25 September 2017

Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide

1 reference

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Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid Pharmacophore

1 reference

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Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile

1 reference

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Bi- or multifunctional opioid peptide drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676711

25 September 2017

Opioid complications and side effects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676711

25 September 2017

Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676711

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Reversal of diastereofacial selectivity in hydride reductions of N-tert-butanesulfinyl imines

1 reference

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Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics

1 reference

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25 September 2017

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

1 reference

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The [35S]GTPγS binding assay: approaches and applications in pharmacology

1 reference

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25 September 2017

Interactions between kappa opioid agonists and cocaine. Preclinical studies

1 reference

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Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

1 reference

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25 September 2017

Synthesis and evaluation of 4-substituted piperidines and piperazines as balanced affinity μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676711

17 June 2018

Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).

1 reference

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17 June 2018

An antisense oligodeoxynucleotide to the delta opioid receptor (DOR-1) inhibits morphine tolerance and acute dependence in mice

1 reference

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Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.

1 reference

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One-pot asymmetric synthesis of either diastereomer of tert-butanesulfinyl-protected amines from ketones

1 reference

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Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys

1 reference

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Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice

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The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats

1 reference

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Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models.

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Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice

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Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats

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12 December 2020

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Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid

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Identifiers

10.1021/ACSCHEMNEURO.5B00100

1 reference

Europe PubMed Central

25 September 2017

1 reference

Europe PubMed Central

25 September 2017

1 reference

Europe PubMed Central

25 September 2017

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