(Q41125254)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

title

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

author name string

Maria Jasin

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

language of work or name

English

0 references

publication date

13 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

page(s)

525

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

29 March 2020

copyright license

start time

13 September 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5597640/fullTextXML

inferred from PubMed Central ID database lookup

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53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

27 September 2017

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27 September 2017

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27 September 2017

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Assaying break and nick-induced homologous recombination in mammalian cells using the DR-GFP reporter and Cas9 nucleases

27 September 2017

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27 September 2017

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27 September 2017

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BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability

27 September 2017

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BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

27 September 2017

1 reference

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ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

How unfinished business from S-phase affects mitosis and beyond

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

27 September 2017

1 reference

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MUS81 promotes common fragile site expression.

27 September 2017

1 reference

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Substrate-selective repair and restart of replication forks by DNA translocases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

RNA-guided human genome engineering via Cas9

27 September 2017

1 reference

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A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

27 September 2017

1 reference

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Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.

27 September 2017

1 reference

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Genetic engineering of human pluripotent cells using TALE nucleases

27 September 2017

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A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay

27 September 2017

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Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

27 September 2017

1 reference

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Replication stress induces 53BP1-containing OPT domains in G1 cells

27 September 2017

1 reference

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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

27 September 2017

1 reference

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The DNA Damage Response: Making It Safe to Play with Knives

27 September 2017

1 reference

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Susceptibility pathways in Fanconi's anemia and breast cancer

27 September 2017

1 reference

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Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Molecular characterization of the t(3;9) associated with immortalization in the MCF10A cell line

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Involvement of Brca2 in DNA repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Two cellular proteins that bind to wild-type but not mutant p53

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5597640

Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1

19 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-017-00634-0

7 January 2021

inferred from DOI database lookup

A large deletion disrupts the exon 3 transcription activation domain of the BRCA2 gene in a breast/ovarian cancer family

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28904335

12 December 2020

inferred from PubMed ID database lookup

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28904335

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41467-017-00634-0

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28904335%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

PubMed publication ID

28904335

1 reference