(Q41282208)

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Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule

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Europe PubMed Central

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29 September 2017

Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule (English)

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Europe PubMed Central

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29 September 2017

Colleen M. Niswender

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Colleen M Niswender

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29 September 2017

P. Jeffrey Conn

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P Jeffrey Conn

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29 September 2017

Craig W. Lindsley

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Craig W Lindsley

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29 September 2017

Patrick R Gentry

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Patrick R Gentry

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29 September 2017

Bruce J. Melancon

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Bruce J Melancon

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29 September 2017

Michael S Poslusney

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Michael S Poslusney

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29 September 2017

Douglas J Sheffler

4

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Douglas J Sheffler

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29 September 2017

author name string

Thomas M Bridges

5

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29 September 2017

Thomas J Utley

6

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29 September 2017

J Scott Daniels

7

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29 September 2017

Michael R Wood

11

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29 September 2017

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publication date

11 January 2013

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29 September 2017

Bioorganic & Medicinal Chemistry Letters

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29 September 2017

23

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29 September 2017

6

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29 September 2017

1860-1864

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Europe PubMed Central

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29 September 2017

Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode

1 reference

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1 October 2017

Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.

1 reference

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1 October 2017

Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease

1 reference

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1 October 2017

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

1 reference

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1 October 2017

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

1 reference

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1 October 2017

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594472

1 October 2017

Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor

1 reference

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1 October 2017

Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

1 reference

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1 October 2017

Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

1 reference

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1 October 2017

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

1 reference

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1 October 2017

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594472

1 October 2017

Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594472

14 June 2018

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594472

14 June 2018

Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594472

14 June 2018

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594472

14 June 2018

Identifiers

10.1016/J.BMCL.2013.01.017

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Europe PubMed Central

PMC publication ID

29 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

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