(Q41487882)

English

Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.

scientific article published on July 2006

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scholarly article

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Europe PubMed Central

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30 August 2019

Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate (English)

1 reference

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30 August 2019

farnesyl pyrophosphate synthase

0 references

farnesyl pyrophosphate synthase

0 references

1 reference

based on heuristic

inferred from title

Leishmania major

object named as

Leishmania major

1 reference

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inferred from title

Antonio M Estévez

3

1 reference

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30 August 2019

Luis Miguel Ruiz-Pérez

5

1 reference

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30 August 2019

Dolores Gonzalez-Pacanowska

6

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30 August 2019

author name string

Aurora Ortiz-Gómez

1

1 reference

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30 August 2019

Carmen Jiménez

2

1 reference

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30 August 2019

Juana Carrero-Lérida

4

1 reference

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30 August 2019

language of work or name

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publication date

1 July 2006

1 reference

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30 August 2019

Eukaryotic Cell

1 reference

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30 August 2019

5

1 reference

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30 August 2019

7

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30 August 2019

1057-1064

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16835450%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations

1 reference

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11 June 2018

Leishmaniasis: current situation and new perspectives

1 reference

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11 June 2018

Mevalonate kinase is a cytosolic enzyme in humans

1 reference

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11 June 2018

Phosphomevalonate kinase is a cytosolic protein in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Cholesterol biosynthesis and regulation: role of peroxisomes.

1 reference

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11 June 2018

Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs

1 reference

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11 June 2018

Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana

1 reference

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11 June 2018

Compartmentation of enzymes in a microbody, the glycosome, is essential in Trypanosoma brucei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Therapeutic approaches to bone diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Molecular analysis of prenyl chain elongating enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Acidocalcisome: A novel Ca2+ storage compartment in trypanosomatids and apicomplexan parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Epidemiology of visceral leishmaniasis in India

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Developments in the therapeutic applications of bisphosphonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Localization of farnesyl diphosphate synthase in chloroplasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Overview of bisphosphonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Compartmentalization of cholesterol biosynthesis. Conversion of mevalonate to farnesyl diphosphate occurs in the peroxisomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Characterization of pyruvate kinase of Trypanosoma brucei and its role in the regulation of carbohydrate metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

11 June 2018

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

Acidocalcisomes are functionally linked to the contractile vacuole of Dictyostelium discoideum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

The intracellular target for the antiresorptive aminobisphosphonate drugs in Dictyostelium discoideum is the enzyme farnesyl diphosphate synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

The Arabidopsis thaliana FPS1 gene generates a novel mRNA that encodes a mitochondrial farnesyl-diphosphate synthase isoform.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

Developmental and stress regulation of gene expression for plastid and cytosolic isoprenoid pathways in pepper fruits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

19 August 2018

Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

4 November 2018

Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489282

2 December 2018

Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes. AA-CoA thiolase, hmg-coa synthase, MPPD, and FPP synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold Dictyostelium discoideum

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-sequestering organelles of Dictyostelium discoideum: changes in element content during early development as measured by electron probe X-ray microanalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships of new heterocycle-containing bisphosphonates as inhibitors of bone resorption and as inhibitors of growth of Dictyostelium discoideum amoebae

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of aminosubstituted analogs of hydroxy bisphosphonates on the growth of Dictyostelium discoideum

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxy-3-methyl-glutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: subcellular localization and kinetic properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of action of bisphosphonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two forms of citrate synthase in a marine Pseudomonad

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Trypanosoma cruzi hexokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16835450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/EC.00034-06

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16835450%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16835450%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16835450%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

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