(Q41517897)

English

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.

scientific article published on 24 August 2017

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scholarly article

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28 March 2020

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways (English)

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28 March 2020

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28 March 2020

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Qiang Yu

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28 March 2020

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Yingqun Zhou

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28 March 2020

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Liwei Wu

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28 March 2020

Qinghui Zhang

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28 March 2020

Wenhui Mo

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28 March 2020

Jiao Feng

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28 March 2020

Sainan Li

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28 March 2020

Jingjing Li

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28 March 2020

Tong Liu

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28 March 2020

Shizan Xu

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28 March 2020

Wenwen Wang

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28 March 2020

Xiya Lu

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28 March 2020

Kan Chen

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28 March 2020

Yujing Xia

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28 March 2020

Jie Lu

14

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28 March 2020

Ling Xu

15

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28 March 2020

Xiaoming Fan

17

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24 August 2017

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28 March 2020

Scientific Reports

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28 March 2020

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28 March 2020

1

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28 March 2020

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28 March 2020

copyright license

Creative Commons Attribution 4.0 International

24 August 2017

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April 2022 Public Data File from Crossref

copyright status

0 references

https://scigraph.springernature.com/pub.10.1038/s41598-017-09673-5

0 references

5-HMF Attenuates Liver Fibrosis in CCl4-Plus-Alcohol-Induced Mice by Suppression of Oxidative Stress

1 reference

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6 June 2018

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway.

1 reference

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Effect of ginseng extract on the TGF-β1 signaling pathway in CCl4-induced liver fibrosis in rats

1 reference

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6 June 2018

Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways

1 reference

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6 June 2018

In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity.

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Oncogenic role of the Notch pathway in primary liver cancer.

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6 June 2018

Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling

1 reference

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6 June 2018

Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis

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6 June 2018

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy.

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Regulation of transforming growth factor-beta1 (TGF-β1)-induced pro-fibrotic activities by circadian clock gene BMAL1.

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Ethyl acetate fraction of Amomum xanthioides improves bile duct ligation-induced liver fibrosis of rat model via modulation of pro-fibrogenic cytokines

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Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-β1 Expression and Autophagy.

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Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice

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The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway

1 reference

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6 June 2018

Protective effects of astaxanthin on ConA-induced autoimmune hepatitis by the JNK/p-JNK pathway-mediated inhibition of autophagy and apoptosis.

1 reference

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6 June 2018

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway.

1 reference

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6 June 2018

N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway.

1 reference

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6 June 2018

Autophagy: a multifaceted partner in liver fibrosis

1 reference

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6 June 2018

Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction

1 reference

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6 June 2018

Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A

1 reference

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Hydrogen sulfide ameliorates ischemia/reperfusion-induced hepatitis by inhibiting apoptosis and autophagy pathways

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Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy.

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6 June 2018

Evaluating the Ameliorative Potential of Quercetin against the Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats

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Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/anti-fibrogenic molecules balance

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Liver fibrosis: searching for cell model answers

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Current research of hepatic cirrhosis in China

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Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling

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Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis

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6 June 2018

PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

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6 June 2018

Activation of hepatic stellate cells--a key issue in liver fibrosis

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6 June 2018

Extracellular matrix degradation and the role of hepatic stellate cells

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Role of transforming growth factor beta in human disease

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6 June 2018

Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis.

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19 August 2018

15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy

1 reference

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19 August 2018

Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis

1 reference

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19 August 2018

Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis

1 reference

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19 August 2018

Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo.

1 reference

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19 August 2018

The flavonoid quercetin ameliorates liver damage in rats with biliary obstruction

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-09673-5

21 January 2018

Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Dietary flavonoids: intake, health effects and bioavailability

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-09673-5

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-09673-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatic stellate cells and liver fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28839277

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/28839277

12 December 2020

based on heuristic

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Identifiers

10.1038/S41598-017-09673-5

1 reference

Europe PubMed Central

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28 March 2020

1 reference

Europe PubMed Central

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28 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28839277%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

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