(Q41598194)

5 March 2018

title

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex (English)

1 reference

5 March 2018

G protein-coupled receptor

main subject

0 references

cryogenic electron microscopy

0 references

author

Thomas Coudrat

10

1 reference

5 March 2018

Denise Wootten

16

1 reference

5 March 2018

Georgios Skiniotis

17

Georgios Skiniotis

1 reference

5 March 2018

15

Brian K Kobilka

1 reference

5 March 2018

Yan Zhang

4

0 references

David M Thal

David M Thal

7

0 references

Arthur Christopoulos

Arthur Christopoulos

14

0 references

Alisa Glukhova

Alisa Glukhova

5

0 references

author name string

Yi-Lynn Liang

1

1 reference

5 March 2018

Maryam Khoshouei

2

1 reference

5 March 2018

Mazdak Radjainia

3

1 reference

5 March 2018

Jeffrey Tarrasch

6

1 reference

5 March 2018

Sebastian G B Furness

8

1 reference

5 March 2018

George Christopoulos

9

1 reference

5 March 2018

Radostin Danev

11

1 reference

5 March 2018

Wolfgang Baumeister

12

1 reference

5 March 2018

Laurence J Miller

13

1 reference

5 March 2018

Patrick M Sexton

18

1 reference

5 March 2018

language of work or name

English

0 references

publication date

24 April 2017

1 reference

5 March 2018

published in

Nature

1 reference

5 March 2018

volume

546

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5 March 2018

issue

7656

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5 March 2018

page(s)

118-123

1 reference

5 March 2018

https://scigraph.springernature.com/pub.10.1038/nature22327

exact match

0 references

cites work

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Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

6 June 2018

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6 June 2018

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6 June 2018

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A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

6 June 2018

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6 June 2018

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2D Projection Analysis of GPCR Complexes by Negative Stain Electron Microscopy

6 June 2018

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How cryo-EM is revolutionizing structural biology

6 June 2018

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Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

6 June 2018

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6 June 2018

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6 June 2018

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Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

6 June 2018

1 reference

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Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.

6 June 2018

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6 June 2018

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Molecular basis for negative regulation of the glucagon receptor

6 June 2018

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Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors

6 June 2018

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Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex

6 June 2018

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

6 June 2018

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Consequences of splice variation on Secretin family G protein-coupled receptor function

6 June 2018

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Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.

6 June 2018

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6 June 2018

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Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

6 June 2018

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Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization

6 June 2018

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6 June 2018

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6 June 2018

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The impact of GPCR structures on pharmacology and structure-based drug design

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832441

Agonist-dependent consequences of proline to alanine substitution in the transmembrane helices of the calcitonin receptor

6 June 2018

1 reference

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Structural Determinants of Salmon Calcitonin Bioactivity

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832441

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6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832441

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832441

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6 June 2018

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6 June 2018

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International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors

6 June 2018

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The ribosome at improved resolution: new techniques for merging and orientation refinement in 3D cryo-electron microscopy of biological particles

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832441

Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832441

Operational models of pharmacological agonism.

6 June 2018

1 reference

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N-terminal truncation of salmon calcitonin leads to calcitonin antagonists. Structure activity relationship of N-terminally truncated salmon calcitonin fragments in vitro and in vivo

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832441

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832441

CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

19 August 2018

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19 August 2018

1 reference

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Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.

19 August 2018

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Quercetin Enhances Cisplatin Sensitivity of Human Osteosarcoma Cells by Modulating microRNA-217-KRAS Axis

19 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22327

Identification of key components in the irreversibility of salmon calcitonin binding to calcitonin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22327

inferred from DOI database lookup

7 January 2021

based on heuristic

Glycosylation is important for binding to human calcitonin receptors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22327

inferred from DOI database lookup

7 January 2021

based on heuristic

Two-dimensional NMR and structure determination of salmon calcitonin in methanol

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22327

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE22327

1 reference

5 March 2018

PMCID

5832441

1 reference

5 March 2018

PubMed ID

28437792

1 reference

5 March 2018