(Q41673436)

6 October 2017

title

The immunology of asthma (English)

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6 October 2017

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6 October 2017

Bart N Lambrecht

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language of work or name

English

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publication date

1 January 2015

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6 October 2017

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6 October 2017

volume

16

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6 October 2017

issue

1

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6 October 2017

page(s)

45-56

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T-helper type 2-driven inflammation defines major subphenotypes of asthma.

6 October 2017

cites work

1 reference

12 December 2020

New insights into the immunology of chronic obstructive pulmonary disease.

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12 December 2020

Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

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12 December 2020

Effects of an anti-TSLP antibody on allergen-induced asthmatic responses

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12 December 2020

Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma.

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12 December 2020

Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma

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12 December 2020

Increased airway T regulatory cells in asthmatic subjects

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12 December 2020

Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma

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12 December 2020

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.

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12 December 2020

Airway surface mycosis in chronic TH2-associated airway disease.

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12 December 2020

Comparison of viral load in individuals with and without asthma during infections with rhinovirus

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12 December 2020

A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma

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12 December 2020

Interleukin-17 is a negative regulator of established allergic asthma

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12 December 2020

The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial.

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12 December 2020

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice

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12 December 2020

IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease

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12 December 2020

Asthma phenotypes: the evolution from clinical to molecular approaches

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12 December 2020

Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation.

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12 December 2020

Effects of omalizumab on markers of inflammation in patients with allergic asthma

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12 December 2020

Selective control of SIRP-α–positive airway dendritic cell trafficking through CD47 is critical for the development of TH2-mediated allergic inflammation

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12 December 2020

Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

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12 December 2020

Diesel exhaust particle induction of IL-17A contributes to severe asthma

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12 December 2020

Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma

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12 December 2020

Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion

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12 December 2020

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

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12 December 2020

Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma

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12 December 2020

Engagement of Fc epsilon RI on human monocytes induces the production of IL-10 and prevents their differentiation in dendritic cells

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12 December 2020

An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation.

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12 December 2020

Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma

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12 December 2020

Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands

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12 December 2020

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

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12 December 2020

Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

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12 December 2020

Necessary and sufficient role for T helper cells to prevent fungal dissemination in allergic lung disease

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12 December 2020

Association between neutrophilic airway inflammation and airflow limitation in adults with asthma.

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12 December 2020

TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice

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12 December 2020

Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes

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12 December 2020

MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion

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12 December 2020

Evidence of a role of tumor necrosis factor alpha in refractory asthma

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12 December 2020

IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation

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12 December 2020

Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells

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12 December 2020

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures

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12 December 2020

Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells.

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12 December 2020

Regulatory T cells negatively regulate neovasculature of airway remodeling via DLL4-Notch signaling

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12 December 2020

OX40 signaling favors the induction of T(H)9 cells and airway inflammation

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12 December 2020

CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status

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12 December 2020

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation.

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12 December 2020

Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse

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12 December 2020

Airway inflammation and illness severity in response to experimental rhinovirus infection in asthma

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12 December 2020

CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling

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12 December 2020

Airway eosinophils accumulate in the mediastinal lymph nodes but lack antigen-presenting potential for naive T cells

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12 December 2020

An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.

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12 December 2020

IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs

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12 December 2020

Directed antigen targeting in vivo identifies a role for CD103+ dendritic cells in both tolerogenic and immunogenic T-cell responses

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12 December 2020

Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways

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12 December 2020

Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4.

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12 December 2020

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma

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12 December 2020

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids

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12 December 2020

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

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12 December 2020

Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3.

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12 December 2020

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

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12 December 2020

Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study

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12 December 2020

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.

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12 December 2020

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation.

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12 December 2020

Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells

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12 December 2020

Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

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12 December 2020

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung

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12 December 2020

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

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12 December 2020

Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation

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12 December 2020

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial

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12 December 2020

IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in Mice

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12 December 2020

Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation.

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12 December 2020

Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance

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12 December 2020

Requirement for IL-13 independently of IL-4 in experimental asthma

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12 December 2020

Lebrikizumab treatment in adults with asthma

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12 December 2020

Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice

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12 December 2020

Il-13 and IFN-gamma: interactions in lung inflammation

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12 December 2020

IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo

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12 December 2020

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.

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12 December 2020

IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma

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12 December 2020

Interleukin-13: central mediator of allergic asthma

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12 December 2020

In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma

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12 December 2020

Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI)

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12 December 2020

Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites

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12 December 2020

The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.

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12 December 2020

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

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12 December 2020

Dectin-2 promotes house dust mite-induced T helper type 2 and type 17 cell differentiation and allergic airway inflammation in mice.

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12 December 2020

A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma

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12 December 2020

Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy

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12 December 2020

Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia

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12 December 2020

Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production

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12 December 2020

Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma

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12 December 2020

Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions

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12 December 2020

Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients

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12 December 2020

Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling

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12 December 2020

Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity

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12 December 2020

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

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12 December 2020

Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production

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12 December 2020

Cationic protein-induced sensory nerve activation: role of substance P in airway hyperresponsiveness and plasma protein extravasation

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12 December 2020

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

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12 December 2020

IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization.

1 reference

12 December 2020

An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation

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12 December 2020

Attenuation of allergic airway inflammation in IL-4 deficient mice.

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12 December 2020

Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.

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12 December 2020

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

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12 December 2020

Mepolizumab treatment in patients with severe eosinophilic asthma

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12 December 2020

Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma

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12 December 2020

Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen

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12 December 2020

Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

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12 December 2020

A20-deficient mast cells exacerbate inflammatory responses in vivo

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12 December 2020

Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma

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12 December 2020

Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation.

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12 December 2020

Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children

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12 December 2020

Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection

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12 December 2020

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

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12 December 2020

CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function

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12 December 2020

The airway epithelium in asthma

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12 December 2020

The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells

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12 December 2020

Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function

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12 December 2020

Mast-cell infiltration of airway smooth muscle in asthma.

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12 December 2020

Amphiregulin, a TH2 cytokine enhancing resistance to nematodes

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12 December 2020

Role of deficient type III interferon-λ production in asthma exacerbations

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12 December 2020

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

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12 December 2020

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

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12 December 2020

Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma

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12 December 2020

Impaired innate interferon induction in severe therapy resistant atopic asthmatic children

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12 December 2020

Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP.

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12 December 2020

Eosinophilic Inflammation in Asthma

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12 December 2020

Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen

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12 December 2020

Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells

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12 December 2020

Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells

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12 December 2020

Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation.

1 reference

12 December 2020

Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation

1 reference

12 December 2020

T-cell activation during exacerbations: a longitudinal study in refractory asthma.

1 reference

12 December 2020

Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo

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12 December 2020

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

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12 December 2020

Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma

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12 December 2020

IL-33-activated dendritic cells are critical for allergic airway inflammation

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12 December 2020

Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation

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12 December 2020

Decreased percentage of CD4(+)Foxp3(+)TGF-β(+) and increased percentage of CD4(+)IL-17(+) cells in bronchoalveolar lavage of asthmatics

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12 December 2020

Atopic dermatitis and the atopic march

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12 December 2020

Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma

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12 December 2020

Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils

1 reference

12 December 2020

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

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12 December 2020

Dual Role of IL-22 in Allergic Airway Inflammation and its Cross-talk with IL-17A

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12 December 2020

STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria.

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12 December 2020

Differentiation of human TH-17 cells does require TGF-β!

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12 December 2020

Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation

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12 December 2020

IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways

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12 December 2020

Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics

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12 December 2020

Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation

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12 December 2020

Basophils are recruited to inflamed lungs and exacerbate memory Th2 responses in mice and humans

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12 December 2020

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

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12 December 2020

Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-alpha via Toll-like receptor 9

1 reference

12 December 2020

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes

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12 December 2020

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

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12 December 2020

Innate lymphoid cells--how did we miss them?

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12 December 2020

Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration

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12 December 2020

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

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12 December 2020

Dupilumab in persistent asthma with elevated eosinophil levels

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12 December 2020

Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

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12 December 2020

Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice.

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12 December 2020

Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice

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12 December 2020

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.

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12 December 2020

Interaction between allergy and innate immunity: model for eosinophil regulation of epithelial cell interferon expression

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12 December 2020

Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology

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12 December 2020

High-Affinity IgE Receptors on Dendritic Cells Exacerbate Th2-Dependent Inflammation

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12 December 2020

Rhinovirus wheezing illness and genetic risk of childhood-onset asthma

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12 December 2020

Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.

1 reference

12 December 2020

IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity

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12 December 2020

Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation.

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12 December 2020

Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation

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12 December 2020

Cross-linking IgE augments human conventional dendritic cell production of CC chemokine ligand 28.

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12 December 2020

Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma

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12 December 2020

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

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12 December 2020

T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production

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12 December 2020

Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling

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12 December 2020

Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation

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12 December 2020

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

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12 December 2020

Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.

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12 December 2020

The complex relationship between inflammation and lung function in severe asthma

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12 December 2020

Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy.

1 reference

12 December 2020

Eosinophil extracellular DNA traps: molecular mechanisms and potential roles in disease

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12 December 2020

Eosinophils Are Dispensable for Allergic Remodeling and Immunity in a Model of House Dust Mite–induced Airway Disease

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12 December 2020

Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma.

1 reference

12 December 2020

Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children

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12 December 2020

Identifiers

DOI

10.1038/NI.3049

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6 October 2017

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