(Q41750955)

8 October 2017

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title

Analysis of antigen receptor signalling using mouse gene targeting. (English)

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8 October 2017

Tybulewicz VL

1

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8 October 2017

1 April 1998

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Current Opinion in Cell Biology

8 October 2017

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8 October 2017

10

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8 October 2017

195-204

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8 October 2017

2

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Signal transduction by lymphocyte antigen receptors

8 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Molecular mechanisms in B cell antigen receptor signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

B cell development and differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Surface IgM-stimulated proliferation, inositol phospholipid hydrolysis, Ca2+ flux, and tyrosine phosphorylation are not altered in B cells from p59fyn-1- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Involvement of p59fynT in interleukin-5 receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Syk tyrosine kinase required for mouse viability and B-cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Xid and Xid-like immunodeficiencies from a signaling point of view.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Defective B cell development and function in Btk-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Impaired expansion of mouse B cell progenitors lacking Btk.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Negative regulation of apoptotic death in immature B cells by CD45.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Role of phosphatases in lymphocyte activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Immunodeficiency in protein kinase cbeta-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

C3d of complement as a molecular adjuvant: bridging innate and acquired immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Tyrosine phosphorylation of CD19 in pre-B and mature B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Counterregulation by the Coreceptors CD19 and CD22 of MAP Kinase Activation by Membrane Immunoglobulin

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Normal lymphocyte development but delayed humoral immune response in CD81-null mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Hyperresponsive B cells in CD22-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

CD22 regulates thymus-independent responses and the lifespan of B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

CD22 is a negative regulator of B-cell receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

T cell antigen receptor signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Positive selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Early alpha beta T cell development in the thymus of normal and genetically altered mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Fyn can partially substitute for Lck in T lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Itk negatively regulates induction of T cell proliferation by CD28 costimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Upstream-downstream: CD28 cosignaling pathways and T cell function.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Differential T cell costimulatory requirements in CD28-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

JNK is involved in signal integration during costimulation of T lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2898%2980142-7

7 January 2021

10.1016/S0955-0674(98)80142-7

Identifiers

DOI

1 reference

8 October 2017

1 reference

PubMed ID

9561844