(Q41771843)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

main subject

traumatic brain injury

0 references

author

Bryan Paul Morgan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Philip F Stahel

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Michael A Flierl

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Ivonne Persigehl

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Christiane Stoll

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Claudia Conrad

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Basel M Touban

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Wade R Smith

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Kathryn Beauchamp

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Oliver I Schmidt

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Wolfgang Ertel

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Iris Leinhase

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

publication date

8 January 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

Journal of Neuroinflammation

19 January 2020

published in

1 reference

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19 January 2020

volume

6

1 reference

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19 January 2020

page(s)

2

1 reference

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https://scigraph.springernature.com/pub.10.1186/1742-2094-6-2

19 January 2020

exact match

0 references

cites work

The role of the complement system in CNS inflammatory diseases

1 reference

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Pharmacology of traumatic brain injury: where is the "golden bullet"?

6 June 2018

1 reference

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Serum biomarker concentrations and outcome after pediatric traumatic brain injury

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Alternative roles for CD59.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Complement regulator loss on apoptotic neuronal cells causes increased complement activation and promotes both phagocytosis and cell lysis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

CD59a deficiency exacerbates ischemia-reperfusion injury in mice

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

The alternative pathway of complement in disease: opportunities for therapeutic targeting

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Central nervous system-targeted complement inhibition mediates neuroprotection after closed head injury in transgenic mice

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Complement therapeutics; history and current progress.

6 June 2018

1 reference

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Spontaneous classical pathway activation and deficiency of membrane regulators render human neurons susceptible to complement lysis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Inhibition of complement as a therapeutic approach in inflammatory central nervous system (CNS) disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Regulation of the complement membrane attack pathway

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Complement C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Role of complement in inflammation and injury in the nervous system

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Complement activation in the central nervous system following blood-brain barrier damage in man.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

The killer molecule of complement

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Insights into the human CD59 complement binding interface toward engineering new therapeutics

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

CD59a is the primary regulator of membrane attack complex assembly in the mouse.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Effects of membrane attack complex of complement on apoptosis in experimental autoimmune encephalomyelitis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Intracerebroventricular injection of the terminal complement complex causes inflammatory reaction in the rat brain.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Intrathecal levels of complement-derived soluble membrane attack complex (sC5b-9) correlate with blood-brain barrier dysfunction in patients with traumatic brain injury.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Activation of the complement cascade and increase of clusterin in the brain following a cortical contusion in the adult rat.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Increased phospholipase C activity after experimental brain injury.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631471

Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis

18 August 2018

1 reference

12 December 2020

Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria

1 reference

12 December 2020

Complement activation in the human brain after traumatic head injury

1 reference

12 December 2020

The Membrane Attack Complex of Complement Causes Severe Demyelination Associated with Acute Axonal Injury

1 reference

12 December 2020

Differential expression of individual complement regulators in the brain and choroid plexus

1 reference

12 December 2020

The role of the complement system in traumatic brain injury

1 reference

12 December 2020

Effect of soluble complement receptor-1 on neutrophil accumulation after traumatic brain injury in rats

1 reference

12 December 2020

Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines

1 reference

12 December 2020

Identifiers

DOI

10.1186/1742-2094-6-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 January 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1742-2094-6-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

19133139

1 reference