(Q41785885)

English

Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability

scientific article published on 21 July 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability (English)

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

0 references

1 reference

based on heuristic

inferred from title

author name string

Federica Vacondio

1

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Claudia Silva

2

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Alessio Lodola

3

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Caterina Carmi

4

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Silvia Rivara

5

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Andrea Duranti

6

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Andrea Tontini

7

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Silvano Sanchini

8

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Jason R Clapper

9

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Daniele Piomelli

10

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Giorgio Tarzia

11

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Marco Mor

12

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

publication date

21 July 2011

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

European Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

46

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

9

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

4466-4473

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors

1 reference

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Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

1 reference

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6 June 2018

Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)

1 reference

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6 June 2018

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors

1 reference

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Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.

1 reference

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Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.

1 reference

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6 June 2018

Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

1 reference

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6 June 2018

Qualitative structure-metabolism relationships in the hydrolysis of carbamates.

1 reference

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6 June 2018

Oxime carbamate--discovery of a series of novel FAAH inhibitors

1 reference

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6 June 2018

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.

1 reference

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6 June 2018

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Targeting the endocannabinoid system: to enhance or reduce?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

A second fatty acid amide hydrolase with variable distribution among placental mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

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Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges

1 reference

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6 June 2018

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Modulation of anxiety through blockade of anandamide hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

Structure-metabolism relationships: steric effects and the enzymatic hydrolysis of carboxylic esters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

6 June 2018

An anorexic lipid mediator regulated by feeding.

1 reference

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6 June 2018

Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes

1 reference

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6 June 2018

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1 reference

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Isolation and structure of a brain constituent that binds to the cannabinoid receptor

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.

1 reference

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1 reference

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18 August 2018

Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

18 August 2018

Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3714604

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Quantitative structure-metabolism relationships: steric and nonsteric effects in the enzymatic hydrolysis of noncongener carboxylic esters.

1 reference

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Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/21820769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21820769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring

1 reference

https://pubmed.ncbi.nlm.nih.gov/21820769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21820769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21820769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EJMECH.2011.07.021

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

ResearchGate publication ID

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