(Q38028659)

27 August 2017

title

Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors (English)

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27 August 2017

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Hongfeng Deng

1

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27 August 2017

language of work or name

English

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publication date

26 August 2010

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Expert Opinion on Drug Discovery

27 August 2017

published in

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27 August 2017

volume

5

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27 August 2017

issue

10

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27 August 2017

page(s)

961-993

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Chemical characterization of a family of brain lipids that induce sleep

27 August 2017

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Structure and function of fatty acid amide hydrolase

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Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

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Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization

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A second fatty acid amide hydrolase with variable distribution among placental mammals

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Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism

21 January 2018

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QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation.

21 January 2018

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Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

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Structure-guided inhibitor design for human FAAH by interspecies active site conversion

21 January 2018

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Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

21 January 2018

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Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures

21 January 2018

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X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

21 January 2018

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Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha

21 January 2018

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Biological functions and metabolism of oleoylethanolamide

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The search for the palmitoylethanolamide receptor.

21 January 2018

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The orphan receptor GPR55 is a novel cannabinoid receptor

21 January 2018

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The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors

21 January 2018

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A FAAH-regulated class of N-acyl taurines that activates TRP ion channels

21 January 2018

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Novel endogenous N-acyl glycines identification and characterization

21 January 2018

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Brain monoglyceride lipase participating in endocannabinoid inactivation

21 January 2018

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The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications

21 January 2018

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Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors

21 January 2018

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Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors

21 January 2018

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Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

21 January 2018

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Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors

21 January 2018

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Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase

21 January 2018

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Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors

21 January 2018

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The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice

21 January 2018

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Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition

21 January 2018

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Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

21 January 2018

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alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution

21 January 2018

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Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics

21 January 2018

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Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.

21 January 2018

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Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase

21 January 2018

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Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).

21 January 2018

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Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

21 January 2018

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Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

3-Heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: design, synthesis and 3D-QSAR studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Oxime carbamate--discovery of a series of novel FAAH inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Structure based design of novel irreversible FAAH inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Mechanistic insights into the inhibition of serine proteases by monocyclic lactams

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Endocannabinoids: friends and foes of reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Endocannabinoids, sperm biology and human fertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Plasma anandamide concentration and pregnancy outcome in women with threatened miscarriage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Genetic loss of Faah compromises male fertility in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Endocannabinoid system in food intake and metabolic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in the anaesthetized rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Cardiovascular pharmacology of anandamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

Is there a role for anandamide in cardiovascular regulation? Insights from studies of endocannabinoid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.513378

10.1517/17460441.2010.513378

21 January 2018

Identifiers

DOI

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27 August 2017

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