(Q43213315)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20024981%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

3-Heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: design, synthesis and 3D-QSAR studies (English)

1 reference

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15 January 2020

8

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15 January 2020

Ari Koskinen

7

1 reference

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15 January 2020

author name string

Heikki Käsnänen

1

1 reference

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15 January 2020

Mikko J Myllymäki

2

1 reference

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15 January 2020

Anna Minkkilä

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20024981%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Antti O Kataja

4

1 reference

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15 January 2020

Susanna M Saario

5

1 reference

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15 January 2020

Tapio Nevalainen

6

1 reference

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15 January 2020

language of work or name

1 reference

1 February 2010

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15 January 2020

1 reference

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15 January 2020

volume

5

1 reference

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15 January 2020

issue

2

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15 January 2020

page(s)

213-231

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Assessing model fit by cross-validation

15 January 2020

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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

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2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain

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Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors

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Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors

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7 January 2021

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Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase

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Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

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7 January 2021

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

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7 January 2021

Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates

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7 January 2021

Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors

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7 January 2021

Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.

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7 January 2021

Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.

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7 January 2021

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

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7 January 2021

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

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7 January 2021

The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition

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7 January 2021

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

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7 January 2021

Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand

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7 January 2021

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.

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7 January 2021

Subcellular Localization and Some Properties of Monoacyiglycerol Lipase in Rat Adipocytes

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7 January 2021

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes

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7 January 2021

Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling

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7 January 2021

A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors

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7 January 2021

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

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Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism

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7 January 2021

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7 January 2021

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7 January 2021

Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures

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7 January 2021

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7 January 2021

Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring

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7 January 2021

Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.

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7 January 2021

QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation.

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7 January 2021

Elucidation of hydrolysis mechanisms for fatty acid amide hydrolase and its Lys142Ala variant via QM/MM simulations

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7 January 2021

Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase

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7 January 2021

Elucidation of fatty acid amide hydrolase inhibition by potent alpha-ketoheterocycle derivatives from Monte Carlo simulations

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7 January 2021

Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling

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7 January 2021

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

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7 January 2021

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

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7 January 2021

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.

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7 January 2021

Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors.

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7 January 2021

Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system

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7 January 2021

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Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors

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7 January 2021

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

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7 January 2021

Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters

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7 January 2021

Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability

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7 January 2021

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7 January 2021

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7 January 2021

On Selection of Training and Test Sets for the Development of Predictive QSAR models

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Stochastic versus stepwise strategies for quantitative structure-activity relationship generation--how much effort may the mining for successful QSAR models take?

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7 January 2021

Sample-distance partial least squares: PLS optimized for many variables, with application to CoMFA

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7 January 2021

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7 January 2021

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7 January 2021

Three-dimensional quantitative structure-activity relationships and activity predictions of human TRPV1 channel antagonists: comparative molecular field analysis and comparative molecular similarity index analysis of cinnamides

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7 January 2021

Statistical variation in progressive scrambling

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7 January 2021

The Importance of Being Earnest: Validation is the Absolute Essential for Successful Application and Interpretation of QSPR Models

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7 January 2021

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7 January 2021

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

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7 January 2021

Generating Optimal Linear PLS Estimations (GOLPE): An Advanced Chemometric Tool for Handling 3D-QSAR Problems

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7 January 2021

A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo

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7 January 2021

New potent C2-symmetric malaria plasmepsin I and II inhibitors

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7 January 2021

(Hydroxyphenyl)carbenes(1)(,)(2)

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7 January 2021

Structural essentials of xenoestrogen dialkyl phthalates to bind to the estrogen receptors

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7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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7 January 2021

[Gamma-35S]GTP autoradiography allows region-specific detection of muscarinic receptor-dependent G-protein activation in the chick optic tectum

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7 January 2021

Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Boosted leave-many-out cross-validation: the effect of training and test set diversity on PLS statistics

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7 January 2021

Comparative molecular similarity index analysis (CoMSIA) to study hydrogen-bonding properties and to score combinatorial libraries

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7 January 2021

Three-dimensional quantitative structure-activity relationship analyses using comparative molecular field analysis and comparative molecular similarity indices analysis to elucidate selectivity differences of inhibitors binding to trypsin, thrombin,

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7 January 2021