(Q41885302)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

title

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

main subject

protein ubiquitination

1 reference

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Barrie Kellam

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

6

Karen H Vousden

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

author name string

Michael P Dickens

1

1 reference

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27 February 2020

Patricia Roxburgh

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Andreas Hock

3

1 reference

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27 February 2020

Mokdad Mezna

4

1 reference

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27 February 2020

language of work or name

English

0 references

publication date

25 September 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json

Bioorganic & Medicinal Chemistry

27 February 2020

published in

1 reference

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27 February 2020

volume

21

1 reference

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27 February 2020

issue

22

1 reference

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27 February 2020

page(s)

6868-6877

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json

Small-molecule inhibitors of MDM2 as new anticancer therapeutics

27 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Antitumor studies. Part 5: Synthesis, antitumor activity, and molecular docking study of 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Molecular basis for the inhibition of p53 by Mdmx

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

p53 in health and disease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Themes and variations on ubiquitylation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Isoalloxazine derivatives promote photocleavage of natural RNAs at G.U base pairs embedded within helices

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Regulation of p53 stability by Mdm2

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Irreversible enzyme inhibitors. CXXI. Thymidine phosphorylase. IX. On the nature and dimensions of the hydrophobic bonding region.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Flavins as potential antimalarials. 1. 10-(halophenyl)-3-methylflavins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Electrochemical characteristics of nitroheterocyclic compounds of biological interest. VIII. Stability of nitro radical anions from cyclic voltammetric studies

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Flavin and 5-deazaflavin: A chemical evaluation of ‘modified’ flavoproteins with respect to the mechanisms of redox biocatalysis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Small molecules that bind the Mdm2 RING stabilize and activate p53.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898830

Redox potential of oligonucleotide linked to 5-deazaflavin coenzyme model. Detection of hybrid formation by cyclic voltammometry

2 December 2018

1 reference

12 December 2020

Syntheses of isoalloxazines and isoalloxazine 5-oxides. A new synthesis of riboflavin

1 reference

12 December 2020

The interaction of reduced metronidazole with DNA

1 reference

12 December 2020

Base specific interaction of reductively activated nitroimidazoles with DNA

1 reference

12 December 2020

Convenient syntheses of oligonucleotides linked to 5-deazaflavin coenzyme models at 3'-end. Incorporation of 5-deazaflavin to controlled pore glass (CPG) support

1 reference

12 December 2020

Assay for ubiquitin ligase activity: high-throughput screen for inhibitors of HDM2

1 reference

12 December 2020

Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon?

1 reference

12 December 2020

10.1016/J.BMC.2013.09.038

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24113239%20AND%20SRC:MED&resulttype=core&format=json