(Q53188125)

12 May 2018

title

Small molecules that bind the Mdm2 RING stabilize and activate p53. (English)

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12 May 2018

author

Peter M. Fischer

5

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12 May 2018

Karen Vousden

6

object named as

Karen H Vousden

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12 May 2018

author name string

Patricia Roxburgh

1

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12 May 2018

Andreas K Hock

2

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12 May 2018

Michael P Dickens

3

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12 May 2018

Mokdad Mezna

4

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12 May 2018

language of work or name

English

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publication date

2 February 2012

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12 May 2018

published in

Carcinogenesis

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12 May 2018

volume

33

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12 May 2018

issue

4

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12 May 2018

page(s)

791-798

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12 May 2018

Mapping of the p53 and mdm-2 interaction domains

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1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS092

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Mdm2 promotes the rapid degradation of p53

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

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Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

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Regulation of HDM2 activity by the ribosomal protein L11

21 January 2018

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

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p53 mutations in human cancers

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Inactivation of p14ARF as a key event for the progression of adult T cell leukemia/lymphoma.

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

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21 January 2018

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Restoration of p53 function leads to tumour regression in vivo

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21 January 2018

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21 January 2018

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Structure-based design of potent non-peptide MDM2 inhibitors

21 January 2018

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

21 January 2018

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Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

21 January 2018

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Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

21 January 2018

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Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design

21 January 2018

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

21 January 2018

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NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

21 January 2018

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Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

21 January 2018

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Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells

21 January 2018

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Regulating the p53 system through ubiquitination

21 January 2018

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Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

21 January 2018

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A field guide to ubiquitylation

21 January 2018

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Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

21 January 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

21 January 2018

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Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors

21 January 2018

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A high-throughput screen measuring ubiquitination of p53 by human mdm2.

21 January 2018

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The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS092

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS092

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS092

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGS092

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGS092

1 reference

12 May 2018

PubMed ID

22301280

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12 May 2018