(Q41894180)

English

Structure-activity relationships in peptide modulators of β-amyloid protein aggregation: variation in α,α-disubstitution results in altered aggregate size and morphology

scientific article published on 8 July 2010

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scholarly article

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7 February 2020

Structure-activity relationships in peptide modulators of β-amyloid protein aggregation: variation in α,α-disubstitution results in altered aggregate size and morphology (English)

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Europe PubMed Central

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7 February 2020

protein aggregation

1 reference

based on heuristic

inferred from title

Robin L McCarley

6

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Europe PubMed Central

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7 February 2020

author name string

Cyrus K Bett

1

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7 February 2020

Johnpeter N Ngunjiri

2

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7 February 2020

Wilson K Serem

3

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7 February 2020

Krystal R Fontenot

4

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7 February 2020

Robert P Hammer

5

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7 February 2020

Jayne C Garno

7

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7 February 2020

publication date

8 July 2010

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7 February 2020

ACS Chemical Neuroscience

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Europe PubMed Central

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7 February 2020

1

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7 February 2020

9

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7 February 2020

608-626

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22778850%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Amyloid oligomers: formation and toxicity of Abeta oligomers

1 reference

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5 June 2018

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

1 reference

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5 June 2018

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5 June 2018

Recent advances in the identification of gamma-secretase inhibitors to clinically test the Abeta oligomer hypothesis of Alzheimer's disease

1 reference

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5 June 2018

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

1 reference

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5 June 2018

Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's beta-amyloid peptide.

1 reference

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5 June 2018

Alzheimer's Abeta peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)?

1 reference

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5 June 2018

Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils

1 reference

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5 June 2018

The role of amyloid beta peptide 42 in Alzheimer's disease

1 reference

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5 June 2018

New insights into the mechanism of Alzheimer amyloid-beta fibrillogenesis inhibition by N-methylated peptides

1 reference

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5 June 2018

The molecular mechanisms of the anti-amyloid effects of phenols

1 reference

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5 June 2018

Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway

1 reference

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5 June 2018

A beta oligomers - a decade of discovery

1 reference

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5 June 2018

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

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5 June 2018

Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: Evaluating the O-O repulsion for extracting H-bond energies

1 reference

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5 June 2018

Generic hydrophobic residues are sufficient to promote aggregation of the Alzheimer's Abeta42 peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Opposing activities protect against age-onset proteotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

1 reference

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5 June 2018

Mechanisms of amyloid fibril self-assembly and inhibition. Model short peptides as a key research tool

1 reference

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5 June 2018

Molecular recycling within amyloid fibrils

1 reference

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5 June 2018

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Hsp20, a novel alpha-crystallin, prevents Abeta fibril formation and toxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Techniques to study amyloid fibril formation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Metabolite-initiated protein misfolding may trigger Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Stereoselective interactions of peptide inhibitors with the beta-amyloid peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Alzheimer's disease is a synaptic failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Control of peptide conformation by the Thorpe-Ingold effect (C alpha-tetrasubstitution).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Design and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Abeta1-40 fibrillogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

A possible role for pi-stacking in the self-assembly of amyloid fibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Acidic pH promotes the formation of toxic fibrils from beta-amyloid peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of beta-amyloid peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Monitoring the assembly of Ig light-chain amyloid fibrils by atomic force microscopy.

1 reference

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5 June 2018

Recognition sequence design for peptidyl modulators of beta-amyloid aggregation and toxicity.

1 reference

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5 June 2018

Inhibition of amyloid formation: a strategy to delay the onset of Alzheimer's disease.

1 reference

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5 June 2018

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy

1 reference

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5 June 2018

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

1 reference

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5 June 2018

Controlling amyloid beta-peptide fibril formation with protease-stable ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

5 June 2018

Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

1 reference

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5 June 2018

Structural characteristics of alpha-helical peptide molecules containing Aib residues

1 reference

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5 June 2018

The molecular pathology of Alzheimer's disease

1 reference

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5 June 2018

Diversity of kinetic pathways in amyloid fibril formation

1 reference

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Targeting the early steps of Abeta16-22 protofibril disassembly by N-methylated inhibitors: a numerical study.

1 reference

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Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation.

1 reference

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18 August 2018

Beta-amyloid protein aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368689

18 August 2018

Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition

1 reference

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18 August 2018

Modulation of amyloid-beta aggregation and toxicity by inosose stereoisomers

1 reference

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18 August 2018

Effects of hydrophobic and dipole-dipole interactions on the conformational transitions of a model polypeptide.

1 reference

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18 August 2018

Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation.

1 reference

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18 August 2018

Structure and orientation of peptide inhibitors bound to beta-amyloid fibrils.

1 reference

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18 August 2018

Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation

1 reference

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18 August 2018

Critical balance of electrostatic and hydrophobic interactions is required for beta 2-microglobulin amyloid fibril growth and stability

1 reference

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18 August 2018

Amyloid-beta protofibrils differ from amyloid-beta aggregates induced in dilute hexafluoroisopropanol in stability and morphology.

1 reference

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18 August 2018

Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy

1 reference

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Facile synthesis of alpha,alpha-diisobutylglycine and anchoring its derivatives onto PAL-PEG-PS resin

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18 August 2018

The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations

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18 August 2018

Hierarchical assembly of beta2-microglobulin amyloid in vitro revealed by atomic force microscopy

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18 August 2018

Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions.

1 reference

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18 August 2018

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

1 reference

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18 August 2018

Inhibitors of fibril formation and cytotoxicity of beta-amyloid peptide composed of KLVFF recognition element and flexible hydrophilic disrupting element.

1 reference

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18 August 2018

Sterically hindered C(alpha, alpha)-disubstituted alpha-amino acids: synthesis from alpha-nitroacetate and incorporation into peptides

1 reference

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18 August 2018

Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues

1 reference

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18 August 2018

Structure-function relationships for inhibitors of beta-amyloid toxicity containing the recognition sequence KLVFF.

1 reference

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18 August 2018

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

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18 August 2018

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease.

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18 August 2018

Physical, morphological and functional differences between ph 5.8 and 7.4 aggregates of the Alzheimer's amyloid peptide Abeta

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18 August 2018

Insights into the amyloid folding problem from solid-state NMR

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3 November 2018

Aggregation of Abeta(1-42) in the presence of short peptides: conformational studies

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stoichiometric inhibition of amyloid beta-protein aggregation with peptides containing alternating alpha,alpha-disubstituted amino acids

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https://pubmed.ncbi.nlm.nih.gov/22778850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Watching amyloid fibrils grow by time-lapse atomic force microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/22778850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational behavior of C alpha,alpha-diphenyl glycine: extended conformation in tripeptides containing consecutive D phi G residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arrest of beta-amyloid fibril formation by a pentapeptide ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A strategy for designing inhibitors of beta-amyloid toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient acylation of the N-terminus of highly hindered C(alpha)(alpha)-disubstituted amino acids via amino acid symmetrical anhydrides

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/CN100045Q

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22778850%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

release_3qfvlr34ofgrbiasffa62uazwy

1 reference

https://api.fatcat.wiki/v0/release/3qfvlr34ofgrbiasffa62uazwy

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22778850%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22778850%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

ResearchGate publication ID

0 references

Sitelinks

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