(Q42015385)

15 October 2017

The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ. (English)

1 reference

15 October 2017

Aliaksei Shymanets

1

1 reference

15 October 2017

Mohammad R Ahmadian

2

1 reference

15 October 2017

Katja T Kössmeier

3

1 reference

15 October 2017

Reinhard Wetzker

4

1 reference

15 October 2017

Christian Harteneck

5

1 reference

15 October 2017

Bernd Nürnberg

6

1 reference

15 October 2017

language of work or name

English

0 references

publication date

1 February 2012

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15 October 2017

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15 October 2017

441

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15 October 2017

3

1 reference

15 October 2017

851-858

1 reference

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

15 October 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Fine tuning the immune response with PI3K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Phosphoinositide signalling in cancer: beyond PI3K and PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

PI3K kinase and scaffold functions in heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Key role of phosphoinositide 3-kinase class IB in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The emerging mechanisms of isoform-specific PI3K signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

PI3K inhibition in inflammation: Toward tailored therapies for specific diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Signalling through Class I PI3Ks in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Form and flexibility in phosphoinositide 3-kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Gbeta 5gamma 2 is a highly selective activator of phospholipid-dependent enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Signal amplification between Gbetagamma release and PI3Kgamma-mediated PI(3,4,5)P3 formation monitored by a fluorescent Gbetagamma biosensor protein and repetitive two component total internal reflection/fluorescence redistribution after photobleach

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The 2.0 A crystal structure of a heterotrimeric G protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Molecular basis for interactions of G protein betagamma subunits with effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

G protein betagamma subunits as targets for small molecule therapeutic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Gbetagamma-copurified lipid kinase impurity from Sf9 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

G protein beta gamma subunit: physical and chemical characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Analysis of class I phosphoinositide 3-kinase autophosphorylation sites by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

G protein mechanisms: insights from structural analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

PI3K p110β: More Tightly Controlled or Constitutively Active?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

21 January 2018

Identifiers

DOI

10.1042/BJ20111664

1 reference

15 October 2017

1 reference