(Q42022551)

15 October 2017

title

Availability predictions by hepatic elimination models for Michaelis-Menten kinetics (English)

1 reference

15 October 2017

1

1 reference

15 October 2017

J D Donaldson

2

1 reference

15 October 2017

D Jackett

series ordinal

3

1 reference

15 October 2017

publication date

1 December 1989

1 reference

Journal of Pharmacokinetics and Pharmacodynamics

15 October 2017

published in

1 reference

15 October 2017

volume

17

1 reference

15 October 2017

issue

6

1 reference

15 October 2017

page(s)

687-719

1 reference

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

15 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Hepatic elimination of flowing substrates: the distributed model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Models of hepatic drug clearance: discrimination between the ‘well stirred’ and ‘parallel-tube’ models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Protein binding and hepatic clearance: discrimination between models of hepatic clearance with diazepam, a drug of high intrinsic clearance, in the isolated perfused rat liver preparation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Hepatic clearance of drugs. III. Additional experimental evidence supporting the "well-stirred" model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liver in situ pr

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

An understanding of the role of enzyme localization of the liver on metabolite kinetics: a computer simulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

An enzyme-distributed system for lidocaine metabolism in the perfused rat liver preparation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

On the uptake of materials by the intact liver. The concentrative transport of rubidium-86.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

On the uptake of materials by the intact liver. The transport and net removal of galactose

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Physiologically based models and strategic experiments in hepatic pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Kinetics of galactose uptake by perfused rat livers: applicability of a family of models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Kinetics of hepatic transport of 4-methylumbelliferone in rats. Analysis by multiple indicator dilution method

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Clinical applicability of current pharmacokinetic models: splanchnic elimination of 5-fluorouracil in cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01062125

Flow dependence of first-order uptake of substances by heterogeneous perfused organs

21 January 2018

1 reference

12 December 2020

Functional implications of liver cell heterogeneity.

1 reference

12 December 2020

Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver

1 reference

12 December 2020

A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

1 reference

12 December 2020

Metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs

1 reference

12 December 2020

Current models of hepatic pharmacokinetics: flow effects on kinetic constants of ethanol elimination in perfused rat liver

1 reference

12 December 2020

Hepatic drug clearance model: comparison among the distributed, parallel-tube and well-stirred models

1 reference

12 December 2020

Kinetic interpretation of hepatic multiple-indicator dilution studies

1 reference

12 December 2020

Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin

1 reference

12 December 2020

Uptake of monohydric alcohols by liver: demonstration of a shared enzymic space

1 reference

12 December 2020

Hepatic transport kinetics: effect of anatomic and metabolic heterogeneity on estimates of the average transfer coefficients.

1 reference

12 December 2020

Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats

1 reference

12 December 2020

Flow dependence of propranolol elimination in perfused rat liver

1 reference

12 December 2020

A linear method for determining liver sinusoidal and extravascular volumes

1 reference

12 December 2020

Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

1 reference

12 December 2020

Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance

1 reference

12 December 2020

The terminal hepatic microcirculation in the rat

1 reference

12 December 2020

The hepatic sinusoid is not well-stirred: estimation of the degree of axial mixing by analysis of lobular concentration gradients formed during uptake of thyroxine by the perfused rat liver

1 reference

12 December 2020

Hepatic transport kinetics and plasma disappearance curves: distributed modeling versus conventional approach

1 reference

12 December 2020

Saturation kinetics in hepatic drug removal: a statistical approach to functional heterogeneity

1 reference

12 December 2020

Discrimination between the venous equilibrium and sinusoidal models of hepatic drug elimination in the isolated perfused rat liver by perturbation of propranolol protein binding

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF01062125

1 reference

15 October 2017

1 reference