(Q42158425)

English

Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

scientific article published on 19 December 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins (English)

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

author name string

Mamta Jaiswal

1

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Radovan Dvorsky

2

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Mohammad Reza Ahmadian

3

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

language of work or name

0 references

publication date

19 December 2012

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

288

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

6

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

4486-4500

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

The GTPase-deficient Rnd proteins are stabilized by their effectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Regulation of the DH-PH tandem of guanine nucleotide exchange factor for Rho GTPases by phosphoinositides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Biochemical assays to characterize Rho GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1

1 reference

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29 May 2018

Rho-guanine nucleotide exchange factors during development: Force is nothing without control

1 reference

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29 May 2018

Structure-function relationships of the G domain, a canonical switch motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

1 reference

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29 May 2018

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

1 reference

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29 May 2018

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

1 reference

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29 May 2018

PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.

1 reference

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29 May 2018

Rho and Ras GTPases in axon growth, guidance, and branching

1 reference

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29 May 2018

Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors

1 reference

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29 May 2018

Rho GTPases in hematopoiesis and hemopathies

1 reference

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29 May 2018

Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors

1 reference

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29 May 2018

Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking

1 reference

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29 May 2018

In vitro GEF and GAP assays.

1 reference

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29 May 2018

RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport

1 reference

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29 May 2018

Rho exchange factors in the cardiovascular system.

1 reference

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29 May 2018

The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity

1 reference

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29 May 2018

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

GEFs and GAPs: critical elements in the control of small G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Structural evidence for a common intermediate in small G protein-GEF reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Catching a GEF by its tail

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Role of Rho GTPases and Rho-GEFs in the regulation of cell shape and integrity in fission yeast.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Regulators of Rho GTPases in neuronal development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Evolution of the Rho family of ras-like GTPases in eukaryotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Coupling receptor tyrosine kinases to Rho GTPases--GEFs what's the link

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Biochemical analyses of the Wrch atypical Rho family GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Scaffold proteins dictate Rho GTPase-signaling specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Larger than Dbl: new structural insights into RhoA activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Always look on the bright site of Rho: structural implications for a conserved intermolecular interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

MUSCLE: multiple sequence alignment with high accuracy and high throughput

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Rho-family GTPases: it's not only Rac and Rho (and I like it).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

RHO-GTPases and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Rho GTPase-activating proteins in cell regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Rho GTPases in cell biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Structural determinants for the biological activity of Vav proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

The two hats of SOS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Crystal structure of Rnd3/RhoE: functional implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Crystal structure of the core domain of RhoE/Rnd3: a constitutively activated small G protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Signaling to the Rho GTPases: networking with the DH domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Rho GTPases in transformation and metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Dbl family guanine nucleotide exchange factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

The guanine nucleotide-binding switch in three dimensions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Rho GTPases in neuronal morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

EPS8 and E3B1 transduce signals from Ras to Rac

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Rho GTPases and signaling networks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567697

29 May 2018

The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor

1 reference

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29 May 2018

The Dbl family of oncogenes

1 reference

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29 May 2018

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1 reference

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29 May 2018

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

1 reference

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29 May 2018

Isolation of a new human oncogene from a diffuse B-cell lymphoma.

1 reference

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29 May 2018

Snapshots form a big picture of guanine nucleotide exchange

1 reference

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17 August 2018

Purification and biochemical properties of Rac1, 2, 3 and the splice variant Rac1b

1 reference

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17 August 2018

Comparative functional analysis of the Rac GTPases

1 reference

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17 August 2018

Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.

1 reference

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17 August 2018

Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins

1 reference

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17 August 2018

EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin

1 reference

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17 August 2018

Tiam1 mutations in human renal-cell carcinomas

1 reference

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17 August 2018

Rho family proteins and Ras transformation: the RHOad less traveled gets congested.

1 reference

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17 August 2018

An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23255595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23255595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23255595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm

1 reference

https://pubmed.ncbi.nlm.nih.gov/23255595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/23255595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF

1 reference

https://pubmed.ncbi.nlm.nih.gov/23255595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of Rac1 and Rac3 GTPases in neuronal development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23255595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sec2 is a Highly Efficient Exchange Factor for the Rab Protein Sec4

1 reference

https://pubmed.ncbi.nlm.nih.gov/23255595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of nucleotide release from Rho by the GDP dissociation stimulator protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23255595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.429746

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

ResearchGate publication ID

0 references

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