(Q42183441)

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Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.

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16 March 2020

Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging (English)

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16 March 2020

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Marc D. Normandin

3

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16 March 2020

Karl E. Richter

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16 March 2020

Veerabahu Shanmugasundaram

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16 March 2020

Debasis Patnaik

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16 March 2020

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Roy Perlis

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16 March 2020

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Steven H Liang

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16 March 2020

Jinshan Michael Chen

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16 March 2020

Jeanne S Chang

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16 March 2020

George C Chang

5

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16 March 2020

Christine K Taylor

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16 March 2020

Patrick Trapa

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16 March 2020

Mark S Plummer

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16 March 2020

Kimberly S Para

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16 March 2020

Edward L Conn

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16 March 2020

Lori Lopresti-Morrow

11

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16 March 2020

Lorraine F Lanyon

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16 March 2020

James M Cook

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16 March 2020

Charlie E Nolan

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16 March 2020

Joel B Schachter

16

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16 March 2020

Fouad Janat

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16 March 2020

Ye Che

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16 March 2020

Bruce A Lefker

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16 March 2020

Bradley E Enerson

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16 March 2020

Elijahu Livni

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16 March 2020

Lu Wang

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16 March 2020

Nicolas J Guehl

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16 March 2020

Florence F Wagner

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16 March 2020

Edward B Holson

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16 March 2020

Stephen J Haggarty

29

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16 March 2020

Georges El Fakhri

30

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16 March 2020

Ravi G Kurumbail

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16 March 2020

Neil Vasdev

32

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16 March 2020

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29 June 2016

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16 March 2020

Angewandte Chemie International Edition

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16 March 2020

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16 March 2020

9601-9605

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16 March 2020

Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4983481

26 October 2017

Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4983481

26 October 2017

Specification of synaptic connectivity by cell surface interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4983481

26 October 2017

Synthesis and Initial in Vivo Studies with [(11)C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4983481

26 October 2017

GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors

1 reference

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26 October 2017

Synthesis and evaluation of [(11)C]PyrATP-1, a novel radiotracer for PET imaging of glycogen synthase kinase-3β (GSK-3β)

1 reference

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26 October 2017

Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque.

1 reference

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26 October 2017

Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease.

1 reference

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26 October 2017

Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties

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26 October 2017

Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease

1 reference

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26 October 2017

Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4983481

26 October 2017

5-Aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4983481

26 October 2017

Different susceptibility to neurodegeneration of dorsal and ventral hippocampal dentate gyrus: a study with transgenic mice overexpressing GSK3β.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4983481

26 October 2017

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

1 reference

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26 October 2017

Radiolabeled small molecule protein kinase inhibitors for imaging with PET or SPECT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4983481

26 October 2017

The GSK3 hypothesis of Alzheimer's disease

1 reference

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26 October 2017

Pharmacological inhibitors of glycogen synthase kinase 3.

1 reference

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26 October 2017

GSK3 inhibitors: development and therapeutic potential

1 reference

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26 October 2017

The glamour and gloom of glycogen synthase kinase-3

1 reference

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26 October 2017

Glycogen synthase kinase-3 as drug target: from wallflower to center of attention

1 reference

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26 October 2017

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4983481

26 October 2017

Molecular cloning and expression of glycogen synthase kinase-3/factor A

1 reference

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26 October 2017

Radiosynthesis and preliminary PET evaluation of glycogen synthase kinase 3β (GSK-3β) inhibitors containing [(11)C]methylsulfanyl, [(11)C]methylsulfinyl or [(11)C]methylsulfonyl groups.

1 reference

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29 May 2018

Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.

1 reference

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17 August 2018

The first synthesis of [(11)C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3).

1 reference

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17 August 2018

GSK3β overexpression induces neuronal death and a depletion of the neurogenic niches in the dentate gyrus.

1 reference

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17 August 2018

Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration.

1 reference

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17 August 2018

Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies.

1 reference

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17 August 2018

Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments.

1 reference

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17 August 2018

Localization and developmental changes of tau protein kinase I/glycogen synthase kinase-3 beta in rat brain.

1 reference

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17 August 2018

Tau in physiology and pathology

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https://api.crossref.org/works/10.1002%2FANIE.201603797

21 January 2018

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10.1002/ANIE.201603797

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16 March 2020

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24 November 2022

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16 March 2020

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16 March 2020

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