(Q42244965)

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Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

scientific article published on 27 September 2013

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scholarly article

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PMC publication ID

19 October 2017

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage (English)

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Europe PubMed Central

PMC publication ID

19 October 2017

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Konstantin Glebov

2

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31 May 2020

5

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31 May 2020

6

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31 May 2020

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Patrick Wunderlich

1

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31 May 2020

Nadja Kemmerling

3

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31 May 2020

Nguyen T Tien

4

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31 May 2020

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27 September 2013

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19 October 2017

Journal of Biological Chemistry

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31 May 2020

288

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31 May 2020

46

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31 May 2020

33027-33036

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24078628%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

TREM2 in Alzheimer's disease

1 reference

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26 October 2017

TREM2 is associated with the risk of Alzheimer's disease in Spanish population

1 reference

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26 October 2017

Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

1 reference

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26 October 2017

TREM2 Variants in Alzheimer's Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

1 reference

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26 October 2017

Linking lipids to Alzheimer's disease: cholesterol and beyond

1 reference

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26 October 2017

γ-Secretase component presenilin is important for microglia β-amyloid clearance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk

1 reference

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26 October 2017

Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Novel research horizons for presenilins and γ-secretases in cell biology and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions

1 reference

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26 October 2017

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Presenilin: running with scissors in the membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Frontotemporal dementia-like phenotypes associated with presenilin-1 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Production of soluble triggering receptor expressed on myeloid cells by lipopolysaccharide-stimulated human neutrophils involves de novo protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

TREMs in the immune system and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Syk regulation of phosphoinositide 3-kinase-dependent NK cell function

1 reference

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26 October 2017

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

1 reference

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26 October 2017

Intramembrane proteolysis by presenilins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

1 reference

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26 October 2017

Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829152

26 October 2017

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

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1 reference

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26 October 2017

Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

1 reference

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26 October 2017

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

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26 October 2017

TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease.

1 reference

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1 reference

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17 August 2018

Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes.

1 reference

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17 August 2018

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

1 reference

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17 August 2018

Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain.

1 reference

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17 August 2018

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

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17 August 2018

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24078628

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24078628

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M113.517540

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24078628%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

release_nyrk5bbujzecvlvqhlu3n55mb4

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https://api.fatcat.wiki/v0/release/nyrk5bbujzecvlvqhlu3n55mb4

24 November 2022

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24078628%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24078628%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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