(Q42271398)

19 October 2017

title

Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor (English)

1 reference

19 October 2017

3

1 reference

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12 June 2020

Eveline Lescrinier

7

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12 June 2020

Zeger Debyser

9

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12 June 2020

Erik V Van der Eycken

10

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12 June 2020

author name string

Claudia Cavalluzzo

1

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12 June 2020

Ajendra Sharma

4

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12 June 2020

Brajendra Kumar Singh

5

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12 June 2020

Kam Y J Zhang

6

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12 June 2020

Frauke Christ

2

1 reference

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12 June 2020

Marc De Maeyer

8

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12 June 2020

publication date

27 August 2013

1 reference

Journal of Peptide Science

19 October 2017

published in

1 reference

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12 June 2020

volume

19

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12 June 2020

issue

10

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12 June 2020

page(s)

651-658

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Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection

12 June 2020

cites work

1 reference

Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro

21 January 2018

1 reference

The future of integrase inhibitors of HIV-1.

21 January 2018

1 reference

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

21 January 2018

1 reference

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

21 January 2018

1 reference

An essential role for LEDGF/p75 in HIV integration

21 January 2018

1 reference

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

21 January 2018

1 reference

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

21 January 2018

1 reference

LEDGF/p75: a novel nuclear autoantigen at the crossroads of cell survival and apoptosis

21 January 2018

1 reference

Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis

21 January 2018

1 reference

Menin critically links MLL proteins with LEDGF on cancer-associated target genes

21 January 2018

1 reference

Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75.

21 January 2018

1 reference

The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?

21 January 2018

1 reference

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

21 January 2018

1 reference

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

21 January 2018

1 reference

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

21 January 2018

1 reference

A role for LEDGF/p75 in targeting HIV DNA integration

21 January 2018

1 reference

Identification of the LEDGF/p75 binding site in HIV-1 integrase

21 January 2018

1 reference

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

21 January 2018

1 reference

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

21 January 2018

1 reference

D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

21 January 2018

1 reference

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

21 January 2018

1 reference

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

21 January 2018

1 reference

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

21 January 2018

1 reference

Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups

21 January 2018

1 reference

Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays.

21 January 2018

1 reference

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

21 January 2018

1 reference

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

21 January 2018

1 reference

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy

21 January 2018

1 reference

Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction

21 January 2018

1 reference

Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.

21 January 2018

1 reference

A hot spot of binding energy in a hormone-receptor interface

21 January 2018

1 reference

Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor

21 January 2018

1 reference

Small peptides mimicking substance P (1-7) and encompassing a C-terminal amide functionality

21 January 2018

1 reference

Reawakening retrocyclins: ancestral human defensins active against HIV-1

21 January 2018

1 reference

The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions

21 January 2018

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

21 January 2018

1 reference

The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

21 January 2018

1 reference

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

21 January 2018

1 reference

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

21 January 2018

1 reference

Anatomy of hot spots in protein interfaces

21 January 2018

1 reference

Pharmacophore modelling as a virtual screening tool for the discovery of small molecule protein-protein interaction inhibitors.

21 January 2018

1 reference

Protein interface pharmacophore mapping tools for small molecule protein: protein interaction inhibitor discovery.

21 January 2018

1 reference