(Q42380665)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

title

Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Ramin Samadani

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Alex MacKerell

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

author name string

Nirav G Shah

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Mohan E Tulapurkar

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Aparna Ramarathnam

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Amanda Brophy

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Ramon Martinez

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Theresa Hodges

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Ishwar S Singh

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Paul Shapiro

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Jeffrey D Hasday

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

language of work or name

English

0 references

publication date

15 March 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

published in

Journal of Immunology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

volume

198

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

page(s)

3296-3306

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

6 April 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5649369/fullTextXML

inferred from PubMed Central ID database lookup

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28 May 2018

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Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease

28 May 2018

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Mitochondrial p38β and manganese superoxide dismutase interaction mediated by estrogen in cardiomyocytes

28 May 2018

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28 May 2018

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DEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation.

28 May 2018

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Global analysis of phosphorylation networks in humans

28 May 2018

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Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone φ, ψ and side-chain χ(1) and χ(2) dihedral angles

28 May 2018

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Toll-like receptor agonists and febrile range hyperthermia synergize to induce heat shock protein 70 expression and extracellular release.

28 May 2018

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Febrile-range hyperthermia augments reversible TNF-α-induced hyperpermeability in human microvascular lung endothelial cells

28 May 2018

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Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery

28 May 2018

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TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α.

28 May 2018

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TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.

28 May 2018

1 reference

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Febrile-range hyperthermia modifies endothelial and neutrophilic functions to promote extravasation

28 May 2018

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The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease

28 May 2018

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p38 mitogen-activated protein kinase pathways in asthma and COPD.

28 May 2018

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Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point

28 May 2018

1 reference

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Automated selection of compounds with physicochemical properties to maximize bioavailability and druglikeness

28 May 2018

1 reference

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Mechanisms and functions of p38 MAPK signalling.

28 May 2018

1 reference

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Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro

28 May 2018

1 reference

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Development of extracellular signal-regulated kinase inhibitors.

28 May 2018

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Signal integration by JNK and p38 MAPK pathways in cancer development

28 May 2018

1 reference

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CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields

28 May 2018

1 reference

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Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury

28 May 2018

1 reference

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The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

28 May 2018

1 reference

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TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia

28 May 2018

1 reference

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MAPKs and their relevance to arthritis and inflammation

28 May 2018

1 reference

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

28 May 2018

1 reference

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Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer

28 May 2018

1 reference

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Generation and characterization of p38beta (MAPK11) gene-targeted mice.

28 May 2018

1 reference

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Scalable molecular dynamics with NAMD

28 May 2018

1 reference

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Identification of novel extracellular signal-regulated kinase docking domain inhibitors.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumonia.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Discovery and characterization of a substrate selective p38alpha inhibitor

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Drug-like properties and the causes of poor solubility and poor permeability

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Exposure to febrile temperature modifies endothelial cell response to tumor necrosis factor-alpha

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

A conserved docking motif in MAP kinases common to substrates, activators and regulators

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

A geometric approach to macromolecule-ligand interactions

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Docking flexible ligands to macromolecular receptors by molecular shape

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Efficacy and safety of the p38 MAPK inhibitor losmapimod for patients with chronic obstructive pulmonary disease: a randomised, double-blind, placebo-controlled trial

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Effects of antioxidants and NO on TNF-alpha-induced adhesion molecule expression in human pulmonary microvascular endothelial cells

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Mobilization of neutrophil sialidase activity desialylates the pulmonary vascular endothelial surface and increases resting neutrophil adhesion to and migration across the endothelium

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Consideration of molecular weight during compound selection in virtual target-based database screening

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Statistical clustering techniques for the analysis of long molecular dynamics trajectories: analysis of 2.2-ns trajectories of YPGDV.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5649369

Unsupervised Data Base Clustering Based on Daylight's Fingerprint and Tanimoto Similarity: A Fast and Automated Way To Cluster Small and Large Data Sets

16 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1602059

Binding Response: A Descriptor for Selecting Ligand Binding Site on Protein Surfaces

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1602059

Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial

21 January 2018

1 reference

12 December 2020

TNF induces distinct gene expression programs in microvascular and macrovascular human endothelial cells

1 reference

12 December 2020

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function

1 reference

12 December 2020

Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation

1 reference

12 December 2020

Anatomy of fingerprint search calculations on structurally diverse sets of active compounds

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1602059

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28298524%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

PubMed publication ID

28298524

1 reference