(Q42509261)

1 November 2017

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway (English)

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1 November 2017

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1 November 2017

3

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1 November 2017

11

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1 November 2017

Rosario Sanchez-Pernaute

object named as

Rosario Sanchez-Pernaute

José Manuel Bravo-San Pedro

9

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1

object named as

José M Bravo-San Pedro

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1 November 2017

Elisa Pizarro-Estrella

4

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1 November 2017

Ana Aiastui-Pujana

5

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1 November 2017

Ana Gorostidi

6

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1 November 2017

Vicente Climent

7

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1 November 2017

Rakel López de Maturana

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1 November 2017

Adolfo López de Munain

10

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1 November 2017

Rosa A González-Polo

12

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1 November 2017

8 July 2012

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Cellular and Molecular Life Sciences

1 November 2017

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1 November 2017

70

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1 November 2017

1

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1 November 2017

121-136

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https://scigraph.springernature.com/pub.10.1007/s00018-012-1061-y

1 November 2017

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cites work

Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Autophagy and neurodegeneration: when the cleaning crew goes on strike

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Identification of the autophosphorylation sites of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

LRRK2 regulates synaptic vesicle endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Development by self-digestion: molecular mechanisms and biological functions of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Silencing DJ-1 reveals its contribution in paraquat-induced autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Autophagy: dual roles in life and death?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

The autophagosomal-lysosomal compartment in programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Autophagy and the integrated stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Autophagy in the eukaryotic cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-alpha-induced cell death in MCF-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

The IKK complex contributes to the induction of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Diagnostic criteria for Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Molecular pathogenesis of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Interaction between α-synuclein and other proteins in neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

alpha-synuclein and LRRK2: partners in crime

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Alpha-synuclein and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Pathological roles of α-synuclein in neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1061-Y

Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*.

21 January 2018

1 reference

12 December 2020

Clean Western blots of membrane proteins after yeast heterologous expression following a shortened version of the method of Perini et al

1 reference

12 December 2020

Autophagy and cancer therapy

1 reference

12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1 reference

12 December 2020

10.1007/S00018-012-1061-Y

Identifiers

DOI

1 reference

1 November 2017

1 reference