(Q42510354)

PubMed publication ID

28553961

1 November 2017

title

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity (English)

1 reference

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12 May 2020

1

1 reference

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12 May 2020

Danny T Huang

7

1 reference

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12 May 2020

6

Karen H Vousden

1 reference

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12 May 2020

author name string

Marta Klejnot

2

1 reference

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12 May 2020

Dominika Kowalczyk

3

1 reference

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12 May 2020

Andreas K Hock

4

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12 May 2020

Gary J Sibbet

5

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12 May 2020

publication date

29 May 2017

1 reference

PubMed publication ID

28553961

Nature Structural & Molecular Biology

1 November 2017

published in

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12 May 2020

volume

24

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12 May 2020

issue

7

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12 May 2020

page(s)

578-587

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describes a project that uses

12 May 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6205632/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nsmb.3414

0 references

cites work

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

21 January 2018

1 reference

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

21 January 2018

1 reference

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

21 January 2018

1 reference

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

21 January 2018

1 reference

MDMX contains an autoinhibitory sequence element

21 January 2018

1 reference

MdmX protects p53 from Mdm2-mediated degradation

21 January 2018

1 reference

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

21 January 2018

1 reference

MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination

21 January 2018

1 reference

Turning the RING domain protein MdmX into an active ubiquitin-protein ligase

21 January 2018

1 reference

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

21 January 2018

1 reference

Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity

21 January 2018

1 reference

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

21 January 2018

1 reference

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

21 January 2018

1 reference

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

21 January 2018

1 reference

Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage

21 January 2018

1 reference

Drugging the p53 pathway: understanding the route to clinical efficacy

21 January 2018

1 reference

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

21 January 2018

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development

21 January 2018

1 reference

Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia

21 January 2018

1 reference

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

21 January 2018

1 reference

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

21 January 2018

1 reference

Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53

21 January 2018

1 reference

Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3

21 January 2018

1 reference

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

21 January 2018

1 reference

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

21 January 2018

1 reference

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains

21 January 2018

1 reference

Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitin

21 January 2018

1 reference

Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity

21 January 2018

1 reference

Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.

21 January 2018

1 reference

Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8

21 January 2018

1 reference

Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.

21 January 2018

1 reference

Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers

21 January 2018

1 reference

Mechanism of ubiquitylation by dimeric RING ligase RNF4

21 January 2018

1 reference

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

1 reference

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

1 reference

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

21 January 2018

1 reference

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

21 January 2018

1 reference

Critical role for a central part of Mdm2 in the ubiquitylation of p53.

21 January 2018

1 reference

Critical contribution of the MDM2 acidic domain to p53 ubiquitination

21 January 2018

1 reference

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

21 January 2018

1 reference

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

21 January 2018

1 reference

Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy.

21 January 2018

1 reference

AKT mediates actinomycin D-induced p53 expression

21 January 2018

1 reference

MDM2 promotes ubiquitination and degradation of MDMX

21 January 2018

1 reference

DNA damage-induced MDMX degradation is mediated by MDM2.

21 January 2018

1 reference

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

21 January 2018

1 reference

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

21 January 2018

1 reference

Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage

21 January 2018

1 reference

Autoactivation of the MDM2 E3 ligase by intramolecular interaction

21 January 2018

1 reference

Small molecules that bind the Mdm2 RING stabilize and activate p53.

21 January 2018

1 reference

21 January 2018

1 reference

The CCP4 suite: programs for protein crystallography

21 January 2018

1 reference

Likelihood-enhanced fast rotation functions

21 January 2018

1 reference

Coot: model-building tools for molecular graphics

21 January 2018

1 reference

PHENIX: building new software for automated crystallographic structure determination

21 January 2018

1 reference

The contribution of the acidic domain of MDM2 to p53 and MDM2 stability

21 January 2018

1 reference

Analysis of the degradation function of Mdm2.

31 March 2020

1 reference

12 December 2020

The MDM2-p53 interaction.

1 reference

12 December 2020

Hdmx stabilizes Mdm2 and p53

1 reference

12 December 2020

mdmx is a negative regulator of p53 activity in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1038/NSMB.3414

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6205632&resulttype=core&format=json

Dimensions Publication ID

12 May 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6205632&resulttype=core&format=json

12 May 2020

PubMed publication ID

28553961

1 reference