(Q42519840)

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Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome

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Europe PubMed Central

1 November 2017

Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome (English)

1 reference

Europe PubMed Central

1 November 2017

0 references

Emilio J Sanchez-Barcelo

7

1 reference

Europe PubMed Central

1 November 2017

author name string

Andrea Corrales

1

1 reference

Europe PubMed Central

1 November 2017

Paula Martínez

2

1 reference

Europe PubMed Central

1 November 2017

Susana García

3

1 reference

Europe PubMed Central

1 November 2017

Verónica Vidal

4

1 reference

Europe PubMed Central

1 November 2017

Eva García

5

1 reference

Europe PubMed Central

1 November 2017

Jesús Flórez

6

1 reference

Europe PubMed Central

1 November 2017

Carmen Martínez-Cué

8

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Europe PubMed Central

1 November 2017

Noemí Rueda

9

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Europe PubMed Central

1 November 2017

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publication date

25 January 2013

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Europe PubMed Central

1 November 2017

Journal of Pineal Research

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Europe PubMed Central

1 November 2017

54

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Europe PubMed Central

1 November 2017

346-358

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Europe PubMed Central

1 November 2017

3

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Europe PubMed Central

1 November 2017

Down syndrome and Alzheimer's disease: a link between development and aging

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Beta-amyloid, oxidative stress and down syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

The use of mouse models to understand and improve cognitive deficits in Down syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Is it possible to improve neurodevelopmental abnormalities in Down syndrome?

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Cognitive functions of the basal forebrain

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

The chromosome 21 transcription factor ETS2 transactivates the beta-APP promoter: implications for Down syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin--a pleiotropic, orchestrating regulator molecule

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin as a natural ally against oxidative stress: a physicochemical examination.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Emergence of naturally occurring melatonin isomers and their proposed nomenclature

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

The ageing pineal gland and its physiological consequences

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Formation of a place learning-set by the rat: a new paradigm for neurobehavioral studies.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin improves D-galactose-induced aging effects on behavior, neurogenesis, and lipid peroxidation in the mouse dentate gyrus via increasing pCREB expression.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Comparison of the impact of melatonin on chronic ethanol-induced learning and memory impairment between young and aged rats

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Long-term effects of melatonin or 17 beta-estradiol on improving spatial memory performance in cognitively impaired, ovariectomized adult rats

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Hippocampal CA3-region is crucial for acquisition and memory consolidation in Morris water maze task in mice

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Neurobiological elements of cognitive dysfunction in down syndrome: exploring the role of APP.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

The cholinergic system in aging and neuronal degeneration

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin preserves superoxide dismutase activity in hypoglossal motoneurons of adult rats following peripheral nerve injury

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin stimulates brain glutathione peroxidase activity.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

The Ts65Dn mouse model of Down syndrome shows reduced expression of the Bcl-X(L) antiapoptotic protein in the hippocampus not accompanied by changes in molecular or cellular markers of cell death.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: altered behavior in the elevated plus maze and open field

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Central administration of arginine vasotocin: effects on exploratory behavior in the rat.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Motor dysfunction in a mouse model for Down syndrome.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12037

21 January 2018

Identifiers

10.1111/JPI.12037

1 reference

Europe PubMed Central

1 November 2017

1 reference

Europe PubMed Central

1 November 2017

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