(Q42521464)

1 November 2017

title

Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog (English)

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1 November 2017

main subject

multiple drug resistance

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6

Clifford Lingwood

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1 November 2017

author name string

María Fabiana De Rosa

1

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1 November 2017

Cameron Ackerley

2

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1 November 2017

Bernice Wang

3

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1 November 2017

Shinya Ito

4

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1 November 2017

David M Clarke

5

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1 November 2017

language of work or name

English

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publication date

13 November 2007

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Journal of Biological Chemistry

1 November 2017

published in

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1 November 2017

volume

283

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1 November 2017

issue

8

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1 November 2017

page(s)

4501-4511

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P-glycoprotein--a mediator of multidrug resistance in tumour cells

1 November 2017

cites work

1 reference

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Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

21 January 2018

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Biochemistry of multidrug resistance mediated by the multidrug transporter

21 January 2018

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

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Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetim

21 January 2018

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Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein

21 January 2018

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Pharmacological considerations in the modulation of multidrug resistance

21 January 2018

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Phase I and pharmacokinetic study of paclitaxel in combination with biricodar, a novel agent that reverses multidrug resistance conferred by overexpression of both MDR1 and MRP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Accumulation of glucosylceramides in multidrug-resistant cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Altered sphingolipid metabolism in multidrug-resistant ovarian cancer cells is due to uncoupling of glycolipid biosynthesis in the Golgi apparatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Preferential killing of multidrug-resistant KB cells by inhibitors of glucosylceramide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Retroviral transfection of Madin-Darby canine kidney cells with human MDR1 results in a major increase in globotriaosylceramide and 10(5)- to 10(6)-fold increased cell sensitivity to verocytotoxin. Role of p-glycoprotein in glycolipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Adamantyl globotriaosyl ceramide: a monovalent soluble mimic which inhibits verotoxin binding to its glycolipid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Characterization of Shiga-like toxin I B subunit purified from overproducing clones of the SLT-I B cistron

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705473200

Universal method for the facile production of glycolipid/lipid matrices for the affinity purification of binding ligands.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705473200

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells

21 January 2018

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Improved inhibitors of glucosylceramide synthase

21 January 2018

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A guided tour into subcellular colocalization analysis in light microscopy

21 January 2018

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

1 reference

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Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

P-Glycoprotein in cell cultures: a combined approach to study expression, localisation, and functionality in the confocal microscope.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

The neutral glycosphingolipid globotriaosylceramide promotes fusion mediated by a CD4-dependent CXCR4-utilizing HIV type 1 envelope glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Sphingolipids, cholesterol, and HIV-1: a paradigm in viral fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

A novel soluble analog of the HIV-1 fusion cofactor, globotriaosylceramide (Gb(3)), eliminates the cholesterol requirement for high affinity gp120/Gb(3) interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

The key lesson of family planning programmes for HIV/AIDS control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Catfish egg lectin causes rapid activation of multidrug resistance 1 P-glycoprotein as a lipid translocase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Lipid sorting in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (review).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Reevaluation of the role of the multidrug-resistant P-glycoprotein in cellular cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug resistance in human CEM leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

An anti-CD19 antibody inhibits the interaction between P-glycoprotein (P-gp) and CD19, causes P-gp to translocate out of lipid rafts, and chemosensitizes a multidrug-resistant (MDR) lymphoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Multidrug-resistant cancer cells contain two populations of P-glycoprotein with differently stimulated P-gp ATPase activities: evidence from atomic force microscopy and biochemical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

P-glycoprotein and 'lipid rafts': some ambiguous mutual relationships (floating on them, building them or meeting them by chance?).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Activation of Src family kinase yes induced by Shiga toxin binding to globotriaosyl ceramide (Gb3/CD77) in low density, detergent-insoluble microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Glucosylceramide modulates membrane traffic along the endocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Is the multidrug transporter a flippase?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Dynamic interplay between the neutral glycosphingolipid CD77/Gb3 and the therapeutic antibody target CD20 within the lipid bilayer of model B lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Functionally different pools of Shiga toxin receptor, globotriaosyl ceramide, in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Shiga-like toxin II modifies brain distribution of a P-glycoprotein substrate, doxorubicin, and P-glycoprotein expression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Influence of ceramide metabolism on P-glycoprotein function in immature acute myeloid leukemia KG1a cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Inhibition of P-glycoprotein activity and chemosensitization of multidrug-resistant ovarian carcinoma 2780AD cells by hexanoylglucosylceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705473200

21 January 2018

Identifiers

DOI

10.1074/JBC.M705473200

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1 November 2017

1 reference