(Q42653553)

4 November 2017

The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2. (English)

1 reference

4 November 2017

Malcolm Walkinshaw

4

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Elizabeth Blackburn

series ordinal

3

object named as

Elizabeth Blackburn

1 reference

4 November 2017

Erin G Worrall

1

1 reference

4 November 2017

Liam Worrall

series ordinal

2

1 reference

4 November 2017

Ted R Hupp

series ordinal

5

1 reference

4 November 2017

language of work or name

English

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publication date

19 March 2010

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Journal of Molecular Biology

4 November 2017

15

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based on heuristic

inferred from page(s)

published in

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4 November 2017

398

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4 November 2017

3

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4 November 2017

414-428

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

4 November 2017

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

The central region of HDM2 provides a second binding site for p53.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Chaperone-dependent stabilization and degradation of p53 mutants

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

A function for the RING finger domain in the allosteric control of MDM2 conformation and activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Ubiquitination and degradation of mutant p53.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Separation and detection of large phosphoproteins using Phos-tag SDS-PAGE.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Blinded by the Light: The Growing Complexity of p53

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

The P53 pathway: what questions remain to be explored?

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Binding induced folding in p53-MDM2 complex

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Regulation of Mdm2-directed degradation by the C terminus of p53.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Multiple peptide conformations give rise to similar binding affinities: molecular simulations of p53-MDM2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Solution structure of the C4 zinc finger domain of HDM2.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

MDM2 chaperones the p53 tumor suppressor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

DILIMOT: discovery of linear motifs in proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

p53 in health and disease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Proteolysis: from the lysosome to ubiquitin and the proteasome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

P53 mRNA controls p53 activity by managing Mdm2 functions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2010.03.023

Identifiers

DOI

10.1016/J.JMB.2010.03.023

1 reference

4 November 2017

1 reference