(Q42705625)

5 November 2017

title

Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway (English)

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5 November 2017

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Jia-Qing Yan

1

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5 November 2017

Yu-He Yuan

2

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5 November 2017

Yan-Na Gao

3

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5 November 2017

Ju-Yang Huang

4

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5 November 2017

Kai-Li Ma

5

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5 November 2017

Yan Gao

6

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5 November 2017

Wan-Qing Zhang

7

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5 November 2017

Xiao-Feng Guo

8

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5 November 2017

Nai-Hong Chen

9

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5 November 2017

publication date

16 May 2014

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5 November 2017

published in

Molecular Neurobiology

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5 November 2017

volume

50

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5 November 2017

issue

2

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5 November 2017

page(s)

685-701

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https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

5 November 2017

1 reference

Parkinson's disease: the syndrome, the pathogenesis and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy in neurodegenerative disease: friend, foe or turncoat?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy and neurodegeneration: when the cleaning crew goes on strike

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagic pathways in Parkinson disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy as a regulated pathway of cellular degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Regulation of mammalian autophagy in physiology and pathophysiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy in health and disease: a double-edged sword

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy: in sickness and in health

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy and the integrated stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy in the Pathogenesis of Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Chaperone-mediated autophagy: selectivity pays off.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Eaten alive: a history of macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy: basic principles and relevance to disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy: process and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Regulation mechanisms and signaling pathways of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Regulation of macroautophagy by mTOR and Beclin 1 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Overexpressed alpha-synuclein regulated the nuclear factor-kappaB signal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Complex inhibitory effects of nitric oxide on autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Utilizing flow cytometry to monitor autophagy in living mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

IMM-H004, a novel coumarin derivative compound, protects against amyloid beta-induced neurotoxicity through a mitochondrial-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

A role for ubiquitin in selective autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Guidelines for the use and interpretation of assays for monitoring autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy fights disease through cellular self-digestion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Autophagy gone awry in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Methods in mammalian autophagy research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

How to interpret LC3 immunoblotting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Role of alpha-synuclein in presynaptic dopamine recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

The many faces of α-synuclein: from structure and toxicity to therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Pathological roles of α-synuclein in neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Protein degradation pathways in Parkinson's disease: curse or blessing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Regulation of lamp2a levels in the lysosomal membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

α-Synuclein and protein degradation systems: a reciprocal relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

The alpha-synuclein mutation E46K promotes aggregation in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Familial Parkinson's Disease Mutant E46K α-Synuclein Localizes to Membranous Structures, Forms Aggregates, and Induces Toxicity in Yeast Models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Neurotoxin-based models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Rotenone, paraquat, and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Control of autophagy as a therapy for neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Potential therapeutic applications of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Fighting neurodegeneration with rapamycin: mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Cellular strategies for controlling protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8738-1

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

21 January 2018

1 reference

12 December 2020

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

1 reference

12 December 2020

Genetic contributions to Parkinson's disease

1 reference

12 December 2020

The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle

1 reference

12 December 2020

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

1 reference

12 December 2020

Eating oneself and uninvited guests: autophagy-related pathways in cellular defense

1 reference

12 December 2020

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

12 December 2020

10.1007/S12035-014-8738-1

Identifiers

DOI

1 reference

Dimensions Publication ID

5 November 2017

1051067027

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