(Q38038126)

27 August 2017

title

Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease (English)

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27 August 2017

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Erika Guerrero

1

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Muralidhar L. Hegde

object named as

Muralidhar L Hegde

3

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author name string

P Vasudevaraju

2

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27 August 2017

G B Britton

4

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27 August 2017

K S Rao

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27 August 2017

publication date

26 August 2012

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27 August 2017

published in

Molecular Neurobiology

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27 August 2017

volume

47

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27 August 2017

issue

2

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27 August 2017

page(s)

525-536

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Parkinson's: symptoms, treatments and research

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Parkinson's Disease: Genetics and Pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Parkinson's disease: Role of genetic and environment factors. Involvement in everyday clinical practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

The impact of genetic research on our understanding of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Recent advances in the genetics of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Challenges and complexities of alpha-synuclein toxicity: new postulates in unfolding the mystery associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Snaring the function of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Alpha-synuclein and presynaptic function: implications for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

New directions for neurodegenerative disease therapy: using chemical compounds to boost the formation of mutant protein inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Nitration inhibits fibrillation of human α‐synuclein in vitro by formation of soluble oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

α-Synuclein: membrane interactions and toxicity in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Metalloproteomics and metal toxicology of α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Role of protein conformational dynamics and DNA integrity in relevance to neuronal cell death in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

The genetics of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Expanding the clinical phenotype of SNCA duplication carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Conversion of wild-type alpha-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

A Swedish family with de novo alpha-synuclein A53T mutation: evidence for early cortical dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

A case of late onset sporadic Parkinson's disease with an A53T mutation in alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Protein oxidative modifications in the ageing brain: Consequence for the onset of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Phosphorylation of synucleins by members of the Polo-like kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Certain Metals Trigger Fibrillation of Methionine-oxidized α-Synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Effects of nitration on the structure and aggregation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

The sour side of neurodegenerative disorders: the effects of protein glycation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Hyperglycemia and glycation in diabetic complications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Advanced glycation end products, diabetes, and the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Advanced glycation end products induce in vitro cross-linking of alpha-synuclein and accelerate the process of intracellular inclusion body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Mechanism for the formation of methylglyoxal from triosephosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Role of fructose in glycation and cross-linking of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Glyceraldehyde-derived advanced glycation end products in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Cytosolic O-glycosylation is abundant in nerve terminals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Alpha-synuclein expression localizes to the Golgi apparatus in bovine adrenal medullary chromaffin cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

TAGE (toxic AGEs) hypothesis in various chronic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Metals, oxidative stress and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Advanced glycation endproducts and their pathogenic roles in neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Alzheimer disease: an imbalance of proteolytic regulation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

N(ɛ)-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

The modification of alpha-synuclein by dicarbonyl compounds inhibits its fibril-forming process

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Evidence of oxidative stress in the neocortex in incidental Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8328-Z

Analysis of microtubule-associated protein tau glycation in paired helical filaments.

21 January 2018

1 reference

12 December 2020

Non-enzymatic glycation of proteins: a cause for complications in diabetes.

1 reference

12 December 2020

Ex vivo detection of histone H1 modified with advanced glycation end products

1 reference

12 December 2020

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1 reference

12 December 2020

[Regulation of dopaminergic neuronal death by endogenous dopamine and proteasome activity]

1 reference

12 December 2020

Oligomeric alpha-synuclein and its role in neuronal death

1 reference

12 December 2020

Protein modification by lipid peroxidation products: formation of malondialdehyde-derived N(epsilon)-(2-propenol)lysine in proteins

1 reference

12 December 2020

Role of advanced glycation on aggregation and DNA binding properties of α-synuclein.

1 reference

12 December 2020

Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation

1 reference

12 December 2020

Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation

1 reference

12 December 2020

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

1 reference

12 December 2020

Targeting oligomers in neurodegenerative disorders: lessons from α-synuclein, tau, and amyloid-β peptide

1 reference

12 December 2020

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

1 reference

12 December 2020

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

1 reference

12 December 2020

10.1007/S12035-012-8328-Z

Identifiers

DOI

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Dimensions Publication ID

27 August 2017

1040606261

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1 reference