(Q42706153)

5 November 2017

title

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors (English)

1 reference

5 November 2017

8

1 reference

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12 June 2020

Colin J Henderson

21

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12 June 2020

Harri Lempiäinen

2

1 reference

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12 June 2020

Antonio Vitobello

14

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12 June 2020

C Wolf

22

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12 June 2020

20

Clifford R Elcombe

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12 June 2020

4

Albert Braeuning

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12 June 2020

author name string

Raphaëlle Luisier

1

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12 June 2020

Nina Scherbichler

3

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12 June 2020

Miriam Geissler

5

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12 June 2020

Valerie Dubost

6

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12 June 2020

Arne Müller

7

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12 June 2020

Salah-Dine Chibout

9

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12 June 2020

Hisanori Hara

10

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12 June 2020

Frank Picard

11

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12 June 2020

Diethilde Theil

12

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12 June 2020

Philippe Couttet

13

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12 June 2020

Olivier Grenet

15

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12 June 2020

Bettina Grasl-Kraupp

16

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12 June 2020

Heidrun Ellinger-Ziegelbauer

17

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12 June 2020

John P Thomson

18

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12 June 2020

Richard R Meehan

19

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12 June 2020

Michael Schwarz

23

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12 June 2020

Pierre Moulin

24

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12 June 2020

Rémi Terranova

25

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12 June 2020

Jonathan G Moggs

26

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12 June 2020

language of work or name

1 reference

1 April 2014

1 reference

5 November 2017

published in

Toxicological Sciences

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12 June 2020

volume

139

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12 June 2020

issue

2

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12 June 2020

page(s)

501-511

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Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).

12 June 2020

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Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors

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Role of apoptosis for mouse liver growth regulation and tumor promotion: comparative analysis of mice with high (C3H/He) and low (C57Bl/6J) cancer susceptibility

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Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

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Attenuation of G1 checkpoint function by the non-genotoxic carcinogen phenobarbital

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21 January 2018

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Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

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Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 January 2018

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21 January 2018

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

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Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion

21 January 2018

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Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice

21 January 2018

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

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Physiological significance of polyploidization in mammalian cells

21 January 2018

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E2F8 is essential for polyploidization in mammalian cells

21 January 2018

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The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors

21 January 2018

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Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice

21 January 2018

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Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors

21 January 2018

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Tumor formation in liver of conditional β-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen

21 January 2018

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Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

21 January 2018

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Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia

21 January 2018

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21 January 2018

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Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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