(Q42776375)

7 November 2017

title

Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice (English)

1 reference

7 November 2017

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8

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6 June 2020

Christian Neri

7

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6 June 2020

Karine Merienne

9

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6 June 2020

author name string

Mayada Achour

1

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6 June 2020

Stéphanie Le Gras

2

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6 June 2020

Céline Keime

3

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6 June 2020

Frédéric Parmentier

4

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6 June 2020

François-Xavier Lejeune

5

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6 June 2020

Anne-Laurence Boutillier

6

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6 June 2020

publication date

17 March 2015

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7 November 2017

published in

Human Molecular Genetics

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6 June 2020

volume

24

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6 June 2020

issue

12

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6 June 2020

page(s)

3481-3496

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Acetyltransferases (HATs) as targets for neurological therapeutics

6 June 2020

cites work

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What have we learned from gene expression profiles in Huntington's disease?

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

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Regional and cellular gene expression changes in human Huntington's disease brain

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Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease.

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Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease.

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Targeting H3K4 trimethylation in Huntington disease

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease

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Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models

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Master transcription factors and mediator establish super-enhancers at key cell identity genes

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Selective inhibition of tumor oncogenes by disruption of super-enhancers

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Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

21 January 2018

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GREAT improves functional interpretation of cis-regulatory regions

21 January 2018

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A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease

21 January 2018

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NMDA receptor function in mouse models of Huntington disease

21 January 2018

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Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington's disease transgenic mice prior to the onset of motor symptoms

21 January 2018

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N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice

21 January 2018

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Control of transcriptional elongation

21 January 2018

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c-Myc regulates transcriptional pause release

21 January 2018

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Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes

21 January 2018

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Regulation of multiple dopamine signal transduction molecules by retinoids in the developing striatum

21 January 2018

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Widespread transcription at neuronal activity-regulated enhancers

21 January 2018

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Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease

21 January 2018

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Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

21 January 2018

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Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing.

21 January 2018

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21 January 2018

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Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation

21 January 2018

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Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

21 January 2018

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Differential expression analysis for sequence count data

21 January 2018

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Transcription elongation and tissue-specific somatic CAG instability

21 January 2018

1 reference

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Model-based analysis of ChIP-Seq (MACS)

21 January 2018

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A clustering approach for identification of enriched domains from histone modification ChIP-Seq data

21 January 2018

1 reference

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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

21 January 2018

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21 January 2018

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ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data

21 January 2018

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Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons.

21 January 2018

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21 January 2018

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21 January 2018

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FIMO: scanning for occurrences of a given motif

21 January 2018

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Balancing of Histone H3K4 Methylation States by the Kdm5c/SMCX Histone Demethylase Modulates Promoter and Enhancer Function

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDV099

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25784504%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference