(Q42811747)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24123662%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

title

Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway (English)

1 reference

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27 February 2020

main subject

stem cell self-renewal

1 reference

1 reference

9

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27 February 2020

Sara Cabodi

10

1 reference

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27 February 2020

Beatrice Tassone

2

1 reference

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27 February 2020

Elisa De Luca

7

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27 February 2020

Vincenzo Calautti

13

1 reference

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27 February 2020

12

Pier Paolo Pandolfi

1 reference

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27 February 2020

6

Giusy Tornillo

1 reference

27 February 2020

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author name string

Stefania Saoncella

1

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27 February 2020

Erika Deklic

3

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27 February 2020

Fabio Avolio

4

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27 February 2020

Cristina Jon

5

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27 February 2020

Enzo Di Iorio

8

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27 February 2020

Emilia Turco

11

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27 February 2020

publication date

1 March 2014

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27 February 2020

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27 February 2020

volume

32

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27 February 2020

issue

3

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27 February 2020

page(s)

754-769

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Epithelial stem cells in corneal regeneration and epidermal gene therapy

27 February 2020

cites work

1 reference

Location of corneal epithelial stem cells

21 January 2018

1 reference

Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells

21 January 2018

1 reference

Cell size as a determinant of the clone-forming ability of human keratinocytes

21 January 2018

1 reference

Three clonal types of keratinocyte with different capacities for multiplication

21 January 2018

1 reference

Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface.

21 January 2018

1 reference

Regeneration of squamous epithelia from stem cells of cultured grafts.

21 January 2018

1 reference

Concise review: limbal stem cell deficiency, dysfunction, and distress

21 January 2018

1 reference

Regenerative medicine: An eye to treating blindness

21 January 2018

1 reference

Isoforms of DeltaNp63 and the migration of ocular limbal cells in human corneal regeneration

21 January 2018

1 reference

C/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells.

21 January 2018

1 reference

p63 Is essential for the proliferative potential of stem cells in stratified epithelia

21 January 2018

1 reference

AKT/PKB signaling: navigating downstream

21 January 2018

1 reference

Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells

21 January 2018

1 reference

A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells

21 January 2018

1 reference

Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation

21 January 2018

1 reference

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

21 January 2018

1 reference

A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell

21 January 2018

1 reference

Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.

21 January 2018

1 reference

Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling

21 January 2018

1 reference

AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation

21 January 2018

1 reference

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

21 January 2018

1 reference

Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death.

21 January 2018

1 reference

Physiological roles of PKB/Akt isoforms in development and disease

21 January 2018

1 reference

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

1 reference

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

21 January 2018

1 reference

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

1 reference

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

21 January 2018

1 reference

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

21 January 2018

1 reference

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

21 January 2018

1 reference

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.

21 January 2018

1 reference

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

21 January 2018

1 reference

Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients

21 January 2018

1 reference

The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

1 reference

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

21 January 2018

1 reference

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

21 January 2018

1 reference

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

21 January 2018

1 reference

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

21 January 2018

1 reference

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

21 January 2018

1 reference

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

21 January 2018

1 reference

FoxO3 regulates neural stem cell homeostasis

21 January 2018

1 reference

Drosophila Melted modulates FOXO and TOR activity.

21 January 2018

1 reference

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

21 January 2018

1 reference

Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

21 January 2018

1 reference

Interplay between FOXO, TOR, and Akt.

21 January 2018

1 reference

Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes

21 January 2018

1 reference

Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes.

21 January 2018

1 reference

Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression

21 January 2018

1 reference

Essential role of PDK1 in regulating endothelial cell migration

21 January 2018

1 reference

Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion.

21 January 2018

1 reference

In sickness and in health: Corneal epithelial stem cell biology, pathology and therapy.

21 January 2018

1 reference

Identification and characterization of limbal stem cells

21 January 2018

1 reference

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

21 January 2018

1 reference

21 January 2018

1 reference

The Akt-regulated Forkhead Transcription Factor FOXO3a Controls Endothelial Cell Viability through Modulation of the Caspase-8 Inhibitor FLIP

21 January 2018

1 reference

Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress

21 January 2018

1 reference

FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.

21 January 2018

1 reference

Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells.

21 January 2018

1 reference

Akt isoforms differentially regulate neutrophil functions

21 January 2018

1 reference

Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways

21 January 2018

1 reference

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

21 January 2018

1 reference

Sestrins at the crossroad between stress and aging

21 January 2018

1 reference

FOXO-binding partners: it takes two to tango

21 January 2018

1 reference

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

21 January 2018

1 reference

AKT can be activated in the nucleus.

21 January 2018

1 reference

Akt1 contains a functional leucine-rich nuclear export sequence

21 January 2018

1 reference

MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.

21 January 2018

1 reference

Oligopotent stem cells are distributed throughout the mammalian ocular surface

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/STEM.1565

1 reference

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27 February 2020

1 reference