(Q42817082)

7 November 2017

Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects (English)

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7 November 2017

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Keiran S M Smalley

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7 November 2017

Tim G Eisen

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PubMed ID

11920610

7 November 2017

language of work or name

English

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publication date

1 April 2002

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International Journal of Cancer

7 November 2017

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7 November 2017

98

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7 November 2017

514-522

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7 November 2017

4

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Increasing complexity of Ras signaling.

7 November 2017

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Autocrine and paracrine regulation by cytokines and growth factors in melanoma

21 January 2018

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Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes

21 January 2018

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Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

21 January 2018

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Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

21 January 2018

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Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer

21 January 2018

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RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

21 January 2018

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Dislodgment and accelerated degradation of Ras.

21 January 2018

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Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid

21 January 2018

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Novel Ras antagonist blocks human melanoma growth

21 January 2018

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Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway

21 January 2018

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Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.

21 January 2018

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The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

21 January 2018

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Cytogenetic homogeneity in eight independent sites in a case of malignant melanoma

21 January 2018

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cell differentiation.

21 January 2018

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The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation

21 January 2018

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Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

21 January 2018

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A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

21 January 2018

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Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines

21 January 2018

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Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

21 January 2018

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The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression.

21 January 2018

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Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair

21 January 2018

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Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

21 January 2018

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The function of melanin or six blind people examine an elephant

21 January 2018

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p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression

21 January 2018

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Point mutations in the N-ras oncogene in malignant melanoma and congenital naevi

21 January 2018

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Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes

21 January 2018

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Geranylgeranylated RhoB is sufficient to mediate tissue-specific suppression of Akt kinase activity by farnesyltransferase inhibitors

21 January 2018

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Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice

21 January 2018

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The involvement of p38 mitogen-activated protein kinase in the alpha-melanocyte stimulating hormone (alpha-MSH)-induced melanogenic and anti-proliferative effects in B16 murine melanoma cells

21 January 2018

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Inhibition of the Phosphatidylinositol 3-Kinase/p70S6-Kinase Pathway Induces B16 Melanoma Cell Differentiation

21 January 2018

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Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma

21 January 2018

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Cisplatin and UV radiation induce activation of the stress-activated protein kinase p38gamma in human melanoma cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.10213

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7 November 2017

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PubMed ID

11920610