(Q42820807)

English

Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons.

scientific article published on November 2007

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

Takuma Uo

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Yoshito Kinoshita

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Richard S Morrison

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

language of work or name

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publication date

1 November 2007

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Europe PubMed Central

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9 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

27

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Europe PubMed Central

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9 January 2020

45

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

12198-12210

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-dependent cell death signaling in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of p53 delays apoptosis, but increases ubiquitinated inclusions, in proteasomal inhibitor-treated cultured cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2-family proteins and the role of mitochondria in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death: critical control points

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurons exclusively express N-Bak, a BH3 domain-only Bak isoform that promotes neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription, apoptosis and p53: catch-22.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 in neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-induced p53 runs a transcription-independent death program

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transcriptional targets of p53 in apoptosis control

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic forms of p53 inhibit p53-regulated gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Bcl-2 apoptotic switch in cancer development and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mutations in human cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of free radicals and p53 in neuron apoptosis in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear accumulation of p53 protein following kainic acid-induced seizures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for p53-mediated modulation of neuronal viability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 protein in sympathetic neurons: cytoplasmic localization and no apparent function in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 expression induces apoptosis in hippocampal pyramidal neuron cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax involvement in p53-mediated neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A third-generation lentivirus vector with a conditional packaging system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17989286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3222-05.2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17989286%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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