(Q44497732)

English

p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults

scientific article published in January 2003

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scholarly article

1 reference

Europe PubMed Central

3 December 2017

p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults (English)

1 reference

Europe PubMed Central

3 December 2017

1 reference

based on heuristic

inferred from title

6

object named as

Mark P Mattson

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Europe PubMed Central

3 December 2017

Charles P. Gilman

1

object named as

Charles P Gilman

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Europe PubMed Central

3 December 2017

author name string

Sic L Chan

2

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Europe PubMed Central

3 December 2017

Zhihong Guo

3

1 reference

Europe PubMed Central

3 December 2017

Xiaoxiang Zhu

4

1 reference

Europe PubMed Central

3 December 2017

Nigel Greig

5

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Europe PubMed Central

3 December 2017

publication date

1 January 2003

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Europe PubMed Central

3 December 2017

NeuroMolecular Medicine

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Europe PubMed Central

3 December 2017

3

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Europe PubMed Central

3 December 2017

3

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Europe PubMed Central

3 December 2017

159-172

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Europe PubMed Central

3 December 2017

https://scigraph.springernature.com/pub.10.1385/nmm:3:3:159

0 references

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Regulation of p53 stabilization by DNA damage and protein kinase C.

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Acceleration of cutaneous wound healing by transient p53 inhibition

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Riluzole improves measures of oxidative stress following traumatic spinal cord injury

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Bacterial alkaloids mitigate seizure-induced hippocampal damage and spatial memory deficits.

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Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

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Attenuation of p53 expression protects against focal ischemic damage in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?

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p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity

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The lipid peroxidation product 4-hydroxy-2,3-nonenal increases AP-1-binding activity through caspase activation in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Changes in presynaptic proteins, SNAP-25 and synaptophysin, in the hippocampal CA1 area in ischemic gerbils.

1 reference

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Bax involvement in p53-mediated neuronal cell death

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https://pubmed.ncbi.nlm.nih.gov/12835511

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The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

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Cryopreservation of rat cortical synaptosomes and analysis of glucose and glutamate transporter activities, and mitochondrial function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Postischemic synaptic physiology in area CA1 of the gerbil hippocampus studied in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Characterization of 2',7'-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: estimation on intracellular content of hydrogen peroxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

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A potential role of p53 and WOX1 in mitochondrial apoptosis (review).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

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Mechanisms of p53-dependent apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

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p53 regulates apoptotic retinal ganglion cell death induced by N-methyl-D-aspartate

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

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WAF1, a potential mediator of p53 tumor suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

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The p53 pathway and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

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Phosphorylation of p53, induction of Bax and activation of caspases during beta-lapachone-mediated apoptosis in human prostate epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53, the cellular gatekeeper for growth and division

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

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P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

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Chemical stimulation of synaptosomes modulates alpha -Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

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The role of free radicals and p53 in neuron apoptosis in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

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Nuclear and mitochondrial apoptotic pathways of p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Role of p53 in DNA strand break-induced apoptosis in organotypic slice culture from the mouse cerebellum

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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P53- and CD95-associated apoptosis in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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The p53 tumor suppressor targets a novel regulator of G protein signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

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Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Injury-induced spinal motor neuron apoptosis is preceded by DNA single-strand breaks and is p53- and Bax-dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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based on heuristic

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Evidence for synaptic apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

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https://pubmed.ncbi.nlm.nih.gov/12835511

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Quantitative assessment of the synaptophysin immuno-reactivity of the cortical neuropil in various neurodegenerative disorders with dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

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Mechanisms of synaptic pathology in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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based on heuristic

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

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Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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based on heuristic

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Cerebral ischemia in the rat: ultrastructural and morphometric analysis of synapses in stratum radiatum of the hippocampal CA-1 region.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium

1 reference

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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inferred from PubMed ID database lookup

How to activate p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic and anti-apoptotic synaptic signaling mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerase II poisons and inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

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based on heuristic

inferred from PubMed ID database lookup

p53 activates the mitochondrial death pathway and apoptosis of ventricular myocytes independent of de novo gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/12835511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/NMM:3:3:159

1 reference

Europe PubMed Central

3 December 2017

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1 reference

Europe PubMed Central

3 December 2017

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