(Q42947899)

English

Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts

scientific article published on 17 December 2009

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Europe PubMed Central

PMC publication ID

11 November 2017

Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts (English)

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

embryonal rhabdomyosarcoma

1 reference

based on heuristic

inferred from title

author name string

Karen Fernandez

1

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Yelda Serinagaoglu

2

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Sue Hammond

3

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Laura T Martin

4

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Paul T Martin

5

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

language of work or name

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publication date

17 December 2009

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Europe PubMed Central

PMC publication ID

11 November 2017

The American Journal of Pathology

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Europe PubMed Central

PMC publication ID

11 November 2017

176

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

1

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

416-434

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase

1 reference

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27 May 2018

Mdm2-mediated ubiquitylation: p53 and beyond.

1 reference

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27 May 2018

Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE.

1 reference

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27 May 2018

Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma

1 reference

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27 May 2018

Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors

1 reference

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27 May 2018

PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma

1 reference

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27 May 2018

Genetic modeling of Ras-induced human rhabdomyosarcoma

1 reference

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27 May 2018

PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound

1 reference

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27 May 2018

Altered expression of natively glycosylated alpha dystroglycan in pediatric solid tumors

1 reference

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27 May 2018

Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice

1 reference

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27 May 2018

Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells

1 reference

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27 May 2018

Overexpression of the cytotoxic T cell (CT) carbohydrate inhibits muscular dystrophy in the dyW mouse model of congenital muscular dystrophy 1A.

1 reference

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27 May 2018

Effects of RAS on the genesis of embryonal rhabdomyosarcoma.

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27 May 2018

N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution

1 reference

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27 May 2018

Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycan.

1 reference

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27 May 2018

PAX3 and PAX3-FKHR promote rhabdomyosarcoma cell survival through downregulation of PTEN.

1 reference

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27 May 2018

Leukemia inhibitory factor: a newly identified metastatic factor in rhabdomyosarcomas

1 reference

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27 May 2018

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

1 reference

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27 May 2018

Rhabdomyosarcomas in adults and children: an update

1 reference

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27 May 2018

A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR.

1 reference

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27 May 2018

Mechanisms of disease: congenital muscular dystrophies-glycosylation takes center stage

1 reference

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27 May 2018

An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children's Oncology Group experience

1 reference

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27 May 2018

Nitric oxide-GAPDH-Siah: a novel cell death cascade

1 reference

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27 May 2018

Altered expression of alpha-dystroglycan subunit in human gliomas

1 reference

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27 May 2018

Survivin: an inhibitor of apoptosis in pediatric cancer

1 reference

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27 May 2018

Analysis of dystroglycan regulation and functions in mouse mammary epithelial cells and implications for mammary tumorigenesis

1 reference

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27 May 2018

Dystroglycan: from biosynthesis to pathogenesis of human disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

The dystroglycan complex: from biology to cancer

1 reference

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27 May 2018

Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo

1 reference

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27 May 2018

Evidence that dystroglycan is associated with dynamin and regulates endocytosis

1 reference

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27 May 2018

Dystrophin Dp71 expression is down-regulated during myogenesis: role of Sp1 and Sp3 on the Dp71 promoter activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Aberrant expression, processing and degradation of dystroglycan in squamous cell carcinomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Dystroglycan complex in cancer

1 reference

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27 May 2018

Dystroglycan, a scaffold for the ERK-MAP kinase cascade

1 reference

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27 May 2018

Dystroglycan glycosylation and its role in matrix binding in skeletal muscle

1 reference

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27 May 2018

Dystroglycan expression is frequently reduced in human breast and colon cancers and is associated with tumor progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Dystrophin-glycoprotein complex: post-translational processing and dystroglycan function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Analysis of the PTCH coding region in human rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Alternative and aberrant splicing of MDM2 mRNA in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies

1 reference

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27 May 2018

Muscular dystrophies involving the dystrophin-glycoprotein complex: an overview of current mouse models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group

1 reference

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27 May 2018

Function and genetics of dystrophin and dystrophin-related proteins in muscle

1 reference

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27 May 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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27 May 2018

Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins

1 reference

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27 May 2018

Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma

1 reference

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27 May 2018

Pathologic classification of rhabdomyosarcomas and correlations with molecular studies

1 reference

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27 May 2018

Anomalous dystroglycan in carcinoma cell lines.

1 reference

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27 May 2018

Pax7 is required for the specification of myogenic satellite cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

P53 mutation and MDM2 amplification frequency in pediatric rhabdomyosarcoma tumors and cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Genes, chromosomes, and rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Common musculoskeletal tumors of childhood and adolescence

1 reference

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27 May 2018

Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Characteristics of skeletal muscle in mdx mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Dystrophin isoforms DP71 and DP427 have distinct roles in myogenic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

p53, the cellular gatekeeper for growth and division

1 reference

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27 May 2018

The sarcoglycan complex in the six autosomal recessive limb-girdle muscular dystrophies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in childhood rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Association of childhood rhabdomyosarcoma with neurofibromatosis type I and birth defects

1 reference

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27 May 2018

A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Defective muscle basement membrane and lack of M-laminin in the dystrophic dy/dy mouse

1 reference

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27 May 2018

Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1 reference

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27 May 2018

Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma

1 reference

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27 May 2018

SH3 domain-mediated interaction of dystroglycan and Grb2

1 reference

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27 May 2018

Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex

1 reference

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27 May 2018

Molecular cloning of a murine N-acetylgalactosamine transferase cDNA that determines expression of the T lymphocyte-specific CT oligosaccharide differentiation antigen

1 reference

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27 May 2018

Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome

1 reference

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27 May 2018

Dystrophin: the protein product of the Duchenne muscular dystrophy locus

1 reference

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27 May 2018

Membrane organization of the dystrophin-glycoprotein complex

1 reference

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27 May 2018

Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

27 May 2018

Loss of suppressor-of-fused function promotes tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

16 August 2018

Dystrophin-deficient mdx mice display a reduced life span and are susceptible to spontaneous rhabdomyosarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

16 August 2018

Prognostic significance of activated AKT expression in soft-tissue sarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

16 August 2018

Altered expression and molecular abnormalities of cell-cycle-regulatory proteins in rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

16 August 2018

Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

16 August 2018

Tumor promotion by Mdm2 splice variants unable to bind p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

16 August 2018

Inhibition of dystroglycan binding to laminin disrupts the PI3K/AKT pathway and survival signaling in muscle cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

16 August 2018

Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

16 August 2018

Dystroglycan in development and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

16 August 2018

Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797901

3 November 2018

Reduced expression of dystroglycan in breast and prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duchenne muscular dystrophy-rhabdomyosarcoma, ichthyosis vulgaris/acute monoblastic leukemia: association of rare genetic disorders and childhood malignant diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular basis of muscular dystrophy in the mdx mouse: a point mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical evaluation of dystrophin expression in small round cell tumors of childhood.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dystrophin glycoprotein complex dysfunction: A regulatory link between muscular dystrophy and cancer cachexia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duchenne muscular dystrophy and concomitant metastatic alveolar rhabdomyosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WW and EF hand domains of dystrophin-family proteins mediate dystroglycan binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/20019182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2353/AJPATH.2010.090405

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

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