(Q43289515)

18 November 2017

title

Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1. (English)

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polycystic kidney disease

18 November 2017

main subject

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Jing Zhou

1

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18 November 2017

James Brugarolas

series ordinal

2

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18 November 2017

Luis F Parada

series ordinal

3

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18 November 2017

publication date

19 August 2009

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18 November 2017

published in

Human Molecular Genetics

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18 November 2017

volume

18

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18 November 2017

issue

22

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18 November 2017

page(s)

4428-4441

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Dysregulation of the TSC-mTOR pathway in human disease

18 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

TOR signaling in growth and metabolism

21 January 2018

1 reference

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mTOR, translational control and human disease.

21 January 2018

1 reference

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A cross sectional study of renal involvement in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Tuberous sclerosis and polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Genetics and pathogenesis of polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease--a contiguous gene syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Renal cystic disease in tuberous sclerosis: role of the polycystic kidney disease 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Generalized lacZ expression with the ROSA26 Cre reporter strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Pten regulates neuronal arborization and social interaction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

21 January 2018

Identifiers

DOI

10.1093/HMG/DDP398

1 reference

18 November 2017

1 reference