(Q43865743)

27 November 2017

title

Neprilysin deficiency-dependent impairment of cognitive functions in a mouse model of amyloidosis (English)

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27 November 2017

M Hasan Mohajeri

1

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27 November 2017

David P Wolfer

series ordinal

2

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27 November 2017

publication date

6 February 2009

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27 November 2017

published in

Neurochemical Research

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27 November 2017

volume

34

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27 November 2017

issue

4

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27 November 2017

page(s)

717-726

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Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

27 November 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11064-009-9919-6

Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS11064-009-9919-6

Intact spatial memory in mice with seizure-induced partial lossof hippocampal pyramidal neurons

21 January 2018

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12 December 2020

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

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12 December 2020

Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.

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12 December 2020

Extended analysis of path data from mutant mice using the public domain software Wintrack

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12 December 2020

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

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12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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12 December 2020

Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Selective neurotoxicity of COOH-terminal fragments of the beta-amyloid precursor protein

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12 December 2020

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12 December 2020

Metabolism of amyloid-beta peptide and Alzheimer's disease

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12 December 2020

Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein

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12 December 2020

Impaired conditioned taste aversion learning in APP transgenic mice

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12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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12 December 2020

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

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12 December 2020

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

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12 December 2020

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

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12 December 2020

Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo

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12 December 2020

Alzheimer's disease is a synaptic failure

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12 December 2020

Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments

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12 December 2020

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

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12 December 2020

Neutral endopeptidase modulation of septic shock.

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12 December 2020

Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein

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12 December 2020

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

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12 December 2020

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

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12 December 2020

Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo

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12 December 2020

Oxidized neprilysin in aging and Alzheimer's disease brains

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12 December 2020

Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging

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12 December 2020

Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism

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12 December 2020

Conditioned taste aversion as a learning and memory paradigm.

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12 December 2020

Metabolic regulation of brain Abeta by neprilysin.

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12 December 2020

Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

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12 December 2020

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

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12 December 2020

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo

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12 December 2020

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

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12 December 2020

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

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12 December 2020

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

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12 December 2020

Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices

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12 December 2020

Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit

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12 December 2020

Impaired recognition memory in patients with lesions limited to the hippocampal formation

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12 December 2020

Amyloid, the presenilins and Alzheimer's disease

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12 December 2020

Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation

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12 December 2020

Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning

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12 December 2020

Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid

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12 December 2020

Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

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12 December 2020

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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12 December 2020

Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy

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12 December 2020

Three cases of enduring memory impairment after bilateral damage limited to the hippocampal formation

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12 December 2020

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

1 reference

12 December 2020

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1 reference

12 December 2020

10.1007/S11064-009-9919-6

Identifiers

DOI

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Dimensions Publication ID

27 November 2017

1001766995

0 references

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