(Q44071207)

29 November 2017

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis (English)

1 reference

29 November 2017

Christopher A Willoughby

1

1 reference

29 November 2017

Herbert G Bull

2

1 reference

29 November 2017

Margarita Garcia-Calvo

3

1 reference

29 November 2017

Joanne Jiang

4

1 reference

29 November 2017

Kevin T Chapman

5

1 reference

29 November 2017

Nancy A Thornberry

6

1 reference

29 November 2017

language of work or name

English

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publication date

1 August 2002

1 reference

Bioorganic & Medicinal Chemistry Letters

29 November 2017

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29 November 2017

12

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29 November 2017

16

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29 November 2017

2197-2200

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Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors

29 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

How do cytotoxic lymphocytes kill their targets?

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

Definition and redesign of the extended substrate specificity of granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

Development of orally active nonpeptidic inhibitors of human neutrophil elastase.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900363-3

7 January 2021

10.1016/S0960-894X(02)00363-3

Identifiers

DOI

1 reference

29 November 2017

1 reference