(Q44089698)

29 November 2017

title

Nitroxides as antioxidants: Tempol protects against EO9 cytotoxicity (English)

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29 November 2017

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Ayelet M Samuni

1

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29 November 2017

William DeGraff

series ordinal

2

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29 November 2017

Murali C Krishna

series ordinal

3

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29 November 2017

James B Mitchell

series ordinal

4

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29 November 2017

publication date

1 May 2002

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Molecular and Cellular Biochemistry

29 November 2017

published in

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29 November 2017

volume

234-235

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29 November 2017

issue

1-2

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29 November 2017

page(s)

327-333

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https://scigraph.springernature.com/pub.10.1023/a:1015974126615

29 November 2017

exact match

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cites work

Cardiac reperfusion damage prevented by a nitroxide free radical

1 reference

12 December 2020

Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase

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12 December 2020

Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species

1 reference

12 December 2020

Population pharmacokinetics and dynamics in phase II studies of the novel bioreductive alkylating cytotoxic indoloquinone EO9.

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12 December 2020

Effects of nitroxide stable radicals on juglone cytotoxicity.

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12 December 2020

Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines

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12 December 2020

Nitroxide-stimulated H2O2 decomposition by peroxidases and pseudoperoxidases

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12 December 2020

A novel metal-free low molecular weight superoxide dismutase mimic.

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12 December 2020

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

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12 December 2020

The autoxidation of the reduced forms of EO9

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12 December 2020

Inhibition of lipid peroxidation by spin labels. Relationships between structure and function

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12 December 2020

A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: a study of the EORTC Early Clinical Studies Group (ECSG)

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12 December 2020

Cytotoxicity of commonly used nitroxide radical spin probes

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12 December 2020

EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

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12 December 2020

Cerebroprotective effect of stable nitroxide radicals in closed head injury in the rat.

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12 December 2020

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

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12 December 2020

Spin trapping: ESR parameters of spin adducts

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12 December 2020

A stable nitroxide radical effectively decreases mucosal damage in experimental colitis

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12 December 2020

Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.

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12 December 2020

Modification of relaxation of lipid protons by molecular oxygen and nitroxides.

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12 December 2020

Nitroxyl spin label contrast enhancers for magnetic resonance imaging. Studies of acute toxicity and mutagenesis

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12 December 2020

TEMPOL protects against lens DNA strand breaks and cataract in the x-rayed rabbit

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12 December 2020

Biologically active metal-independent superoxide dismutase mimics

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12 December 2020

DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.

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12 December 2020

Reduction and destruction rates of nitroxide spin probes

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12 December 2020

Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide

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12 December 2020

Bioreductive therapies: an overview of drugs and their mechanisms of action

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12 December 2020

Antimutagenicity of a low molecular weight superoxide dismutase mimic against oxidative mutagens

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12 December 2020

25 Electron spin resonance spin destruction methods for radical detection

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12 December 2020

Modulation of streptonigrin cytotoxicity by nitroxide SOD mimics.

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12 December 2020

Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites

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12 December 2020

Antioxidant activity of nitroxide radicals in lipid peroxidation of rat liver microsomes

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12 December 2020

Superoxide reaction with nitroxides

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12 December 2020

Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells.

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12 December 2020

A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats

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12 December 2020

Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09.

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12 December 2020

Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

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12 December 2020

Viability measurements in mammalian cell systems

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12 December 2020

SOD-like activity of 5-membered ring nitroxide spin labels.

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12 December 2020

Nitroxides block DNA scission and protect cells from oxidative damage

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12 December 2020

Identifiers

DOI

10.1023/A:1015974126615

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Dimensions Publication ID

29 November 2017

1028015059

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