(Q44216067)

17360920

30 November 2017

title

Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice (English)

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30 November 2017

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simian virus 40

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

16 May 2020

author name string

Janice L Hallows

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

16 May 2020

Paramita Chakrabarty

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

16 May 2020

Peter Davies

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

16 May 2020

Inez Vincent

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

16 May 2020

language of work or name

English

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publication date

1 March 2007

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17360920

30 November 2017

published in

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

16 May 2020

volume

27

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

16 May 2020

issue

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

16 May 2020

page(s)

2969-2978

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

16 May 2020

cites work

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Single and multiple transgenic mice as models for Alzheimer's disease

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E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons

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Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases.

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Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

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Vulnerability of select neuronal types to Alzheimer's disease.

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Cellular transformation by SV40 large T antigen: interaction with host proteins

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DNA replication precedes neuronal cell death in Alzheimer's disease.

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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Inducible and reversible beta-cell autoimmunity and hyperplasia in transgenic mice expressing a conditional oncogene

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Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau.

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Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis.

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Commentary: Abeta N- Terminal Isoforms: Critical contributors in the course of AD pathophysiology.

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Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.

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Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease

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Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis

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Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1.

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Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

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Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

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DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3

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Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice.

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APP processing is regulated by cytoplasmic phosphorylation

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The cell cycle and human neurodegenerative disease

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Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.

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Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

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Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats

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Divide and die: cell cycle events as triggers of nerve cell death.

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12 December 2020

Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease

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Alzheimer's disease: Abeta, tau and synaptic dysfunction

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Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation

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Neuronal Ca2+/calmodulin-dependent protein kinase II--discovery, progress in a quarter of a century, and perspective: implication for learning and memory

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12 December 2020

The cell cycle as a therapeutic target for Alzheimer's disease

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12 December 2020

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation

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12 December 2020

Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models

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12 December 2020

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

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Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1.

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Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease.

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Specific distribution of Ca2+/calmodulin-dependent protein kinase II alpha and beta isoforms in some structures of the rat forebrain

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12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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12 December 2020

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

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12 December 2020

Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein

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12 December 2020

Mitotic mechanisms in Alzheimer's disease?

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs

1 reference

12 December 2020

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.

1 reference

12 December 2020

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1 reference

12 December 2020

Cell cycle markers in the hippocampus in Alzheimer's disease.

1 reference

12 December 2020

Diagnostic criteria for neuropathologic assessment of Alzheimer's disease.

1 reference

12 December 2020

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

12 December 2020

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

12 December 2020

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

12 December 2020

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

1 reference

12 December 2020

Regional differences between the immunohistochemical distribution of Ca2+/calmodulin-dependent protein kinase II alpha and beta isoforms in the brainstem of the rat.

1 reference

12 December 2020

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

1 reference

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Inducible and reversible gene expression with the rtTA system for the study of memory.

1 reference

12 December 2020

10.1523/JNEUROSCI.0186-07.2007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672567&resulttype=core&format=json

16 May 2020

17360920

1 reference