(Q44301813)

1 December 2017

Apoptosis induction by the dual-action DNA- and protein-reactive antitumor drug irofulven is largely Bcl-2-independent (English)

1 reference

1 December 2017

Maryanne C S Herzig

1

1 reference

1 December 2017

Alex V Trevino

2

1 reference

1 December 2017

Huiyun Liang

3

1 reference

1 December 2017

Richard Salinas

4

1 reference

1 December 2017

Stephen J Waters

5

1 reference

1 December 2017

John R MacDonald

6

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1 December 2017

Barbara A Woynarowska

7

1 reference

1 December 2017

Jan M Woynarowski

8

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1 December 2017

language of work or name

English

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publication date

1 February 2003

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1 December 2017

Biochemical Pharmacology

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1 December 2017

65

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1 December 2017

4

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1 December 2017

503-513

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Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

1 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Induction of apoptosis by cancer chemotherapy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Apoptosis and metastasis: increased apoptosis resistance of metastatic cancer cells is associated with the profound deficiency of apoptosis execution mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Mitochondria as regulators of apoptosis: doubt no more.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Mitochondria as the central control point of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Bcl-2 family: life-or-death switch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Mitochondria and cell death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

The mitochondrion in cell death control: certainties and incognita

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Overexpression of Bcl-2 protects human hepatoma cells from Fas-antibody-mediated apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Role of the Bcl-2 gene family in prostate cancer progression and its implications for therapeutic intervention

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Regulation of clinical chemoresistance by bcl-2 and bax oncoproteins in B-cell chronic lymphocytic leukaemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Prognostic significance of apoptosis regulators in breast cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Mutated N-ras upregulates Bcl-2 in human melanoma in vitro and in SCID mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

7 January 2021

Bcl-2 family proteins

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Drug-induced apoptosis in chronic lymphocytic leukemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Phase I and pharmacokinetic study of irofulven, a novel mushroom-derived cytotoxin, administered for five consecutive days every four weeks in patients with advanced solid malignancies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Antitumor activity of MGI 114 (6-hydroxymethylacylfulvene, HMAF), a semisynthetic derivative of illudin S, against adult and pediatric human tumor colony-forming units

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

MGI 114: augmentation of antitumor activity when combined with topotecan.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

In vivo antitumour efficacy of MGI-114 (6-hydroxymethylacylfulvene, HMAF) in various human tumour xenograft models including several lung and gastric tumours

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Effects on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene drug, 6-hydroxymethylacylfulvene (HMAF, MGI 114)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Drug uptake and cellular targets of hydroxymethylacylfulvene (HMAF)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Targeting apoptosis by hydroxymethylacylfulvene in combination with gamma radiation in prostate tumor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Differential cytotoxicity and induction of apoptosis in tumor and normal cells by hydroxymethylacylfulvene (HMAF).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Thiol-mediated redox regulation of neutrophil apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Thiol-mediated apoptosis in prostate carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Preferential targeting of apoptosis in tumor versus normal cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Irofulven induces apoptosis in breast cancer cells regardless of caspase-3 status

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Tetracycline-controlled gene expression system achieves high-level and quantitative control of gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Fluorometric assessments of mitochondrial function and viability in cryopreserved bovine spermatozoa

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Analysis of apoptosis by laser scanning cytometry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Flow cytometry of apoptotic cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Differentiation and assessment of cell death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Discrimination of late apoptotic/necrotic cells (type III) by flow cytometry in solid tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Overexpression of bcl-2 enhances LIGHT- and interferon-gamma -mediated apoptosis in Hep3BT2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Bid acts on the permeability transition pore complex to induce apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Sesquiterpene Antitumor Agents: Inhibitors of Cellular Metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Chronic inflammation and cancer: potential role of Bcl-2 gene family members as regulators of cellular antioxidant status

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Redox aspects of Bcl-2 function.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Antioxidant function of thioredoxin and glutaredoxin systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

The role of the redox protein thioredoxin in cell growth and cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Differential expression of cell death regulators in response to thapsigargin and adriamycin in Bcl-2 transfected DU145 prostatic cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

Bcl-2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901552-6

10.1016/S0006-2952(02)01552-6

7 January 2021

Identifiers

DOI

1 reference

1 December 2017

1 reference