(Q44480812)

3 December 2017

title

The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation (English)

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3 December 2017

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6

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3 December 2017

5

Pier Paolo Pandolfi

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3 December 2017

1

Igal Louria-Hayon

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3 December 2017

Tamar Grossman

2

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3 December 2017

Ronit Vogt Sionov

series ordinal

3

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3 December 2017

Osnat Alsheich

series ordinal

4

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3 December 2017

language of work or name

English

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publication date

16 June 2003

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Journal of Biological Chemistry

3 December 2017

published in

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3 December 2017

volume

278

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3 December 2017

issue

35

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3 December 2017

page(s)

33134-33141

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The complexity of p53 modulation: emerging patterns from divergent signals

3 December 2017

cites work

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

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Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20.

21 January 2018

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Regulation of p53 localization

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21 January 2018

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

21 January 2018

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The function of PML in p53-dependent apoptosis

21 January 2018

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

21 January 2018

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Deconstructing PML-induced premature senescence

21 January 2018

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PML is essential for multiple apoptotic pathways

21 January 2018

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

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c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301264200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

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Regulation of p53 stability by Mdm2

21 January 2018

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PML protein isoforms and the RBCC/TRIM motif

21 January 2018

1 reference

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Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301264200

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

21 January 2018

1 reference

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

21 January 2018

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CHK2 kinase--a busy messenger.

21 January 2018

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Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

21 January 2018

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Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation.

21 January 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

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Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

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Mutation of mouse p53 Ser23 and the response to DNA damage

21 January 2018

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PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

21 January 2018

1 reference

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

21 January 2018

1 reference

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Characterization of tumor-associated Chk2 mutations

21 January 2018

1 reference

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Physical and functional interactions between PML and MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301264200

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301264200

Acetylation of p53 inhibits its ubiquitination by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301264200

The transcriptional role of PML and the nuclear body

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301264200

PML interaction with p53 and its role in apoptosis and replicative senescence

21 January 2018

1 reference

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Advances in the treatment of relapsed acute promyelocytic leukemia

21 January 2018

1 reference

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Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M301264200

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3 December 2017

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