(Q44542014)

English

Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression

scientific article published in August 2003

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Jennifer Sigmond

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Harold H J Backus

2

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Dorine Wouters

3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Olaf H Temmink

4

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Gerrit Jansen

5

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Godefridus J Peters

6

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

language of work or name

0 references

publication date

1 August 2003

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Biochemical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

66

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

431-438

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: Enzyme activity and inhibition by 5-fluoro-2′-deoxyuridine-5′-monophosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Future directions in the development of pemetrexed

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Dysregulation of apoptosis in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Apoptosis and chemotherapy resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Karnofsky memorial lecture. Ode to methotrexate

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Glutamyl hydrolase. pharmacological role and enzymatic characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900287-9

7 January 2021

Identifiers

10.1016/S0006-2952(03)00287-9

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q44542014&oldid=2027231803"