(Q44588830)

English

Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition

scientific article published in September 2003

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scholarly article

1 reference

Europe PubMed Central

4 December 2017

Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition (English)

1 reference

Europe PubMed Central

4 December 2017

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based on heuristic

inferred from title

6

object named as

Paul Dent

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Europe PubMed Central

4 December 2017

author name string

Mohamed Rahmani

1

1 reference

Europe PubMed Central

4 December 2017

Chunrong Yu

2

1 reference

Europe PubMed Central

4 December 2017

Erin Reese

3

1 reference

Europe PubMed Central

4 December 2017

Wesam Ahmed

4

1 reference

Europe PubMed Central

4 December 2017

Karen Hirsch

5

1 reference

Europe PubMed Central

4 December 2017

Steven Grant

7

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Europe PubMed Central

4 December 2017

language of work or name

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publication date

1 September 2003

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Europe PubMed Central

4 December 2017

1 reference

Europe PubMed Central

4 December 2017

22

1 reference

Europe PubMed Central

4 December 2017

6231-6242

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Europe PubMed Central

4 December 2017

40

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Europe PubMed Central

4 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206646

0 references

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

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HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

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Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis

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Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells

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The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process

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AKT plays a central role in tumorigenesis

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Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site

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Glucagon-like peptide-2 receptor activation engages bad and glycogen synthase kinase-3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase.

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p21Cip1/WAF1 is important for differentiation and survival of U937 cells

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Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

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Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

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Phosphatidylinositol-3-kinase activation and atypical protein kinase C ζ phosphorylation characterize the DMSO signalling in erythroleukemia cells

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MAPK-dependent expression of p21(WAF) and p27(kip1) in PMA-induced differentiation of HL60 cells

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IAP family proteins--suppressors of apoptosis

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Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy

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Histone acetylation in chromatin structure and transcription

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Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

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Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

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Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase

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Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

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Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells

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Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

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Identifiers

10.1038/SJ.ONC.1206646

1 reference

Europe PubMed Central

4 December 2017

1 reference

Europe PubMed Central

4 December 2017

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