(Q44592773)

4 December 2017

title

C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth (English)

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4 December 2017

main subject

oleic monoethanolamide

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ChEBI release 2020-05-28

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1 reference

Margaret Flowers

1

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4 December 2017

Gemma Fabriás

2

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4 December 2017

Antonio Delgado

3

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4 December 2017

Josefina Casas

4

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4 December 2017

Jose Luis Abad

5

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4 December 2017

Myles C Cabot

6

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4 December 2017

language of work or name

English

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publication date

21 September 2011

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Breast Cancer Research and Treatment

4 December 2017

published in

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4 December 2017

volume

133

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4 December 2017

issue

2

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4 December 2017

page(s)

447-458

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4 December 2017

cites work

Cancer statistics, 2010

1 reference

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Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

21 January 2018

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Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells

21 January 2018

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Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.

21 January 2018

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High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients

21 January 2018

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Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

21 January 2018

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A role of sphingosine kinase 1 in head and neck carcinogenesis

21 January 2018

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Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy

21 January 2018

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Human acid ceramidase is overexpressed but not mutated in prostate cancer

21 January 2018

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Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer

21 January 2018

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Sphingolipids as determinants of apoptosis and chemoresistance in the MCF-7 cell model system

21 January 2018

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Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells

21 January 2018

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Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2

21 January 2018

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Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide

21 January 2018

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FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.

21 January 2018

1 reference

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Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells

21 January 2018

1 reference

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Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs

21 January 2018

1 reference

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Liposomal delivery enhances short-chain ceramide-induced apoptosis of breast cancer cells

21 January 2018

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Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma.

21 January 2018

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Rapid distribution of liposomal short-chain ceramide in vitro and in vivo.

21 January 2018

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Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells

21 January 2018

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Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression

21 January 2018

1 reference

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Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Laser microdissection and microarray analysis of breast tumors reveal ER-alpha related genes and pathways

21 January 2018

1 reference

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Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy

21 January 2018

1 reference

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A bioinformatic approach to the identification of candidate genes for the development of new cancer diagnostics

21 January 2018

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Chemotherapy-induced tumor gene expression changes in human breast cancers

21 January 2018

1 reference

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p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis

21 January 2018

1 reference

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Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials

21 January 2018

1 reference

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Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases

21 January 2018

1 reference

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A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Ceramide mediates tumor-induced dendritic cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Cytotoxicity and acid ceramidase inhibitory activity of 2-substituted aminoethanol amides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Caspase inhibitors promote alternative cell death pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Radiation-induced cell signaling: inside-out and outside-in

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues

21 January 2018

1 reference

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The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Ceramide-induced intracellular oxidant formation, iron signaling, and apoptosis in endothelial cells: protective role of endogenous nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Ceramide in the eukaryotic stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Role for ceramide in cell cycle arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Metabolism of short-chain ceramide by human cancer cells--implications for therapeutic approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Long-chain ceramide produced in response to N-hexanoylsphingosine does not induce apoptosis in CHP-100 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Taxol-induced ceramide generation and apoptosis in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Relevance of breast cancer cell lines as models for breast tumours: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10549-011-1768-8

10.1007/S10549-011-1768-8

21 January 2018

Identifiers

DOI

1 reference

4 December 2017

1 reference