(Q44951464)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

author name string

Ke-Jing Tang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Jerfiz D Constanzo

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Niranjan Venkateswaran

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Margherita Melegari

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Mariya Ilcheva

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Julio C Morales

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Ferdinandos Skoulidis

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

David A Boothman

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

language of work or name

English

0 references

publication date

24 May 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

published in

Clinical Cancer Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

issue

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

page(s)

5851-5863

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

2 April 2020

cites work

1 reference

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25 May 2018

Cancer statistics, 2015

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LKB1 preserves genome integrity by stimulating BRCA1 expression

25 May 2018

1 reference

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FAK in cancer: mechanistic findings and clinical applications

25 May 2018

1 reference

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Comprehensive molecular profiling of lung adenocarcinoma

25 May 2018

1 reference

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Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy.

25 May 2018

1 reference

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Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesis.

25 May 2018

1 reference

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Targeting FAK in human cancer: from finding to first clinical trials

25 May 2018

1 reference

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Genetic screens in human cells using the CRISPR-Cas9 system

25 May 2018

1 reference

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An optimized microRNA backbone for effective single-copy RNAi

25 May 2018

1 reference

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

25 May 2018

1 reference

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Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas

25 May 2018

1 reference

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Comprehensive genomic characterization of squamous cell lung cancers

25 May 2018

1 reference

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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

25 May 2018

1 reference

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Advances in treatment of lung cancer with targeted therapy

25 May 2018

1 reference

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β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

25 May 2018

1 reference

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Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

RAS oncogenes: weaving a tumorigenic web

25 May 2018

1 reference

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Therapeutic strategies for targeting ras proteins

25 May 2018

1 reference

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An orthosteric inhibitor of the Ras-Sos interaction

25 May 2018

1 reference

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Hallmarks of Cancer: The Next Generation

25 May 2018

1 reference

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Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Molecular target class is predictive of in vitro response profile

25 May 2018

1 reference

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Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

25 May 2018

1 reference

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Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

25 May 2018

1 reference

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

25 May 2018

1 reference

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Palliative thoracic radiotherapy for lung cancer: a systematic review.

25 May 2018

1 reference

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Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Analysis of transformation and tumorigenicity using mouse embryonic fibroblast cells

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

LKB1 modulates lung cancer differentiation and metastasis

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Clonogenic assay of cells in vitro.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

A CK2-dependent mechanism for degradation of the PML tumor suppressor

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

PARP-1 modifies the effectiveness of p53-mediated DNA damage response.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

25 May 2018

1 reference

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

25 May 2018

1 reference

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NCI-Navy Medical Oncology Branch cell line data base

25 May 2018

1 reference

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Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Participation of p53 protein in the cellular response to DNA damage

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Molecular biology. Use and abuse of RNAi to study mammalian gene function

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Ras induces chromosome instability and abrogation of the DNA damage response.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Cytometric assessment of histone H2AX phosphorylation: a reporter of DNA damage

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5122471

Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27220963

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran- 5,6-dione), a novel DNA repair inhibitor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27220963

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1078-0432.CCR-15-2603

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27220963%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

PubMed publication ID

27220963

1 reference